David Duggan
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Explore the profile of David Duggan including associated specialties, affiliations and a list of published articles.
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111
Citations
5428
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Recent Articles
1.
Chen Z, Guo X, Tao R, Huyghe J, Law P, Fernandez-Rozadilla C, et al.
Nat Commun
. 2024 Apr;
15(1):3557.
PMID: 38670944
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We...
2.
Huang S, Joshi A, Shi Z, Wei J, Tran H, Zheng S, et al.
Int J Cardiol
. 2024 Mar;
404:131990.
PMID: 38521508
Background: Current risk assessment for ischemic stroke (IS) is limited to clinical variables. We hypothesize that polygenic scores (PGS) of IS (PGS) and IS-associated diseases such as atrial fibrillation (AF),...
3.
Don J, Schork A, Glusman G, Rappaport N, Cummings S, Duggan D, et al.
Geroscience
. 2024 Mar;
46(4):3911-3927.
PMID: 38451433
Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has motivated the development of disease-specific "polygenic scores (PGS)" that are weighted...
4.
Chan J, Clendenning M, Joseland S, Georgeson P, Mahmood K, Joo J, et al.
Fam Cancer
. 2023 Dec;
23(1):9-21.
PMID: 38063999
Genetic susceptibility to familial colorectal cancer (CRC), including for individuals classified as Familial Colorectal Cancer Type X (FCCTX), remains poorly understood. We describe a multi-generation CRC-affected family segregating pathogenic variants...
5.
Shi Z, Wei J, Rifkin A, Wang C, Billings L, Woo J, et al.
Thromb Res
. 2023 Jul;
229:69-72.
PMID: 37419004
Cancer-associated thrombosis (CAT) is common and associated with mortality. We estimated CAT rate by cancer sites and inherited factors among cancer patients from the UK Biobank (N =70,406). The 12-month...
6.
Patel S, Wei J, Shi Z, Rifkin A, Zheng S, Gelfman E, et al.
J Alzheimers Dis
. 2023 Jun;
94(2):483-489.
PMID: 37334598
In a large population-based cohort, we show not all heterozygous APOEɛ4 carriers are at increased risk for Alzheimer's disease (AD); a significantly higher AD proportion was only found for ɛ3/ɛ4,...
7.
Fernandez-Rozadilla C, Timofeeva M, Chen Z, Law P, Thomas M, Schmit S, et al.
Nat Genet
. 2023 Feb;
55(3):519-520.
PMID: 36782065
No abstract available.
8.
Fernandez-Rozadilla C, Timofeeva M, Chen Z, Law P, Thomas M, Schmit S, et al.
Nat Genet
. 2022 Dec;
55(1):89-99.
PMID: 36539618
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry,...
9.
Thomas M, Sakoda L, Hoffmeister M, Rosenthal E, Lee J, van Duijnhoven F, et al.
Am J Hum Genet
. 2021 Mar;
108(3):527-529.
PMID: 33667396
No abstract available.
10.
Huyghe J, Harrison T, Bien S, Hampel H, Figueiredo J, Schmit S, et al.
Gut
. 2021 Feb;
70(7):1325-1334.
PMID: 33632709
Objective: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable...