David Dinsdale
Overview
Explore the profile of David Dinsdale including associated specialties, affiliations and a list of published articles.
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43
Citations
2299
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Recent Articles
11.
Inoue S, Tomasini R, Rufini A, Elia A, Agostini M, Amelio I, et al.
Proc Natl Acad Sci U S A
. 2014 Jan;
111(5):1843-8.
PMID: 24449892
The generation of viable sperm proceeds through a series of coordinated steps, including germ cell self-renewal, meiotic recombination, and terminal differentiation into functional spermatozoa. The p53 family of transcription factors,...
12.
Tufi R, Gandhi S, de Castro I, Lehmann S, Angelova P, Dinsdale D, et al.
Nat Cell Biol
. 2014 Jan;
16(2):157-66.
PMID: 24441527
Mutations in PINK1 cause early-onset Parkinson's disease (PD). Studies in Drosophila melanogaster have highlighted mitochondrial dysfunction on loss of Pink1 as a central mechanism of PD pathogenesis. Here we show...
13.
Niklison-Chirou M, Steinert J, Agostini M, Knight R, Dinsdale D, Cattaneo A, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(47):18952-7.
PMID: 24190996
Total and N-terminal isoform selective p73 knockout mice show a variety of central nervous system defects. Here we show that TAp73 is a transcriptional activator of p75 neurotrophin receptor (p75(NTR))...
14.
Vogler M, Dinsdale D, Dyer M, Cohen G
Br J Haematol
. 2013 Jul;
163(1):139-42.
PMID: 23826785
No abstract available.
15.
Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen G
Neoplasia
. 2013 May;
15(5):568-78.
PMID: 23633928
Owing to the high levels of antiapoptotic B-cell lymphoma 2 (BCL-2) family members observed in several cancers, there has been a major effort to develop inhibitors of the BCL2-family as...
16.
Varadarajan S, Tanaka K, Smalley J, Bampton E, Pellecchia M, Dinsdale D, et al.
PLoS One
. 2013 Mar;
8(2):e56603.
PMID: 23457590
Recently we described a new, evolutionarily conserved cellular stress response characterized by a reversible reorganization of endoplasmic reticulum (ER) membranes that is distinct from canonical ER stress and the unfolded...
17.
Amelio I, Lena A, Viticchie G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, et al.
J Cell Biol
. 2012 Oct;
199(2):347-63.
PMID: 23071155
During keratinocyte differentiation and stratification, cells undergo extensive remodeling of their actin cytoskeleton, which is important to control cell mobility and to coordinate and stabilize adhesive structures necessary for functional...
18.
Rufini A, Niklison-Chirou M, Inoue S, Tomasini R, Harris I, Marino A, et al.
Genes Dev
. 2012 Sep;
26(18):2009-14.
PMID: 22987635
Aging is associated with impaired scavenging of reactive oxygen species (ROS). Here, we show that TAp73, a p53 family member, protects against aging by regulating mitochondrial activity and preventing ROS...
19.
Moreno J, Radford H, Peretti D, Steinert J, Verity N, Martin M, et al.
Nature
. 2012 May;
485(7399):507-11.
PMID: 22622579
The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific...
20.
Napierska D, Rabolli V, Thomassen L, Dinsdale D, Princen C, Gonzalez L, et al.
Chem Res Toxicol
. 2012 Jan;
25(4):828-37.
PMID: 22263782
Amorphous silica nanoparticles (SiO₂-NPs) have found broad applications in industry and are currently intensively studied for potential uses in medical and biomedical fields. Several studies have reported cytotoxic and inflammatory...