David Dinsdale
Overview
Explore the profile of David Dinsdale including associated specialties, affiliations and a list of published articles.
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43
Citations
2299
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Recent Articles
1.
Hellwig C, Delgado M, Skoko J, Dyck L, Hanna C, Wentges A, et al.
Cell Death Differ
. 2021 Aug;
29(1):147-155.
PMID: 34354257
Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show that proteasome inhibition induces the formation of high molecular weight platforms in...
2.
Fox J, Hughes M, Meng X, Sarnowska N, Powley I, Jukes-Jones R, et al.
Nat Commun
. 2021 Feb;
12(1):819.
PMID: 33547302
Regulated cell death is essential in development and cellular homeostasis. Multi-protein platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via a core FADD:Caspase-8 complex and its regulatory partners,...
3.
Kozaki R, Vogler M, Walter H, Jayne S, Dinsdale D, Siebert R, et al.
Cancers (Basel)
. 2018 Apr;
10(4).
PMID: 29690649
Bruton's tyrosine kinase (BTK) is a key regulator of the B-cell receptor signaling pathway, and aberrant B-cell receptor (BCR) signaling has been implicated in the survival of malignant B-cells. However,...
4.
Robinson S, Bourgognon J, Spiers J, Breda C, Campesan S, Butcher A, et al.
PLoS Biol
. 2018 Apr;
16(4):e2003611.
PMID: 29630591
Nitric oxide (NO) regulates neuronal function and thus is critical for tuning neuronal communication. Mechanisms by which NO modulates protein function and interaction include posttranslational modifications (PTMs) such as S-nitrosylation....
5.
Chernova T, Murphy F, Galavotti S, Sun X, Powley I, Grosso S, et al.
Curr Biol
. 2017 Nov;
27(21):3302-3314.e6.
PMID: 29112861
Mesothelioma is a fatal tumor of the pleura and is strongly associated with asbestos exposure. The molecular mechanisms underlying the long latency period of mesothelioma and driving carcinogenesis are unknown....
6.
Amodeo V, A D, Betts J, Bartesaghi S, Zhang Y, Richard-Londt A, et al.
Cell Rep
. 2017 Jul;
20(2):411-426.
PMID: 28700942
Cell migration through the brain parenchyma underpins neurogenesis and glioblastoma (GBM) development. Since GBM cells and neuroblasts use the same migratory routes, mechanisms underlying migration during neurogenesis and brain cancer...
7.
Viticchie G, Agostini M, Lena A, Mancini M, Zhou H, Zolla L, et al.
Proc Natl Acad Sci U S A
. 2015 Sep;
112(37):11577-82.
PMID: 26324887
Short p63 isoform, ΔNp63, is crucial for epidermis formation, and it plays a pivotal role in controlling the turnover of basal keratinocytes by regulating the expression of a subset of...
8.
Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin M, et al.
Nature
. 2015 Jan;
518(7538):236-9.
PMID: 25607368
In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity. Reduction in synapse number is a consistent early feature of...
9.
Luyts K, Napierska D, Dinsdale D, Klein S, Serchi T, Hoet P
Toxicol In Vitro
. 2014 Dec;
29(1):234-41.
PMID: 25448809
We developed a coculture model of the lung–blood barrier using human bronchial epithelial cells(16HBE14o-), monocytes (THP-1) and human lung microvascular endothelial cells (HLMVEC) in which several parameters can be assessed...
10.
Robinson S, Nugent M, Dinsdale D, Steinert J
Hum Mol Genet
. 2014 Apr;
23(17):4581-96.
PMID: 24722203
The cellular prion protein (PrP(C)) has been implicated in several neurodegenerative diseases as a result of protein misfolding. In humans, prion disease occurs typically with a sporadic origin where uncharacterized...