David DeTomaso
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Explore the profile of David DeTomaso including associated specialties, affiliations and a list of published articles.
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8
Citations
477
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Recent Articles
1.
Wang C, Wagner A, Fessler J, DeTomaso D, Zaghouani S, Zhou Y, et al.
bioRxiv
. 2024 Sep;
PMID: 39229227
Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate the relevance of individual glycolytic reactions in determining...
2.
Pawlak M, DeTomaso D, Schnell A, Meyer Zu Horste G, Lee Y, Nyman J, et al.
Immunity
. 2022 Sep;
55(9):1663-1679.e6.
PMID: 36070768
Interleukin-23 receptor plays a critical role in inducing inflammation and autoimmunity. Here, we report that Th1-like cells differentiated in vitro with IL-12 + IL-21 showed similar IL-23R expression to that...
3.
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, et al.
Cell
. 2021 Jul;
184(16):4168-4185.e21.
PMID: 34216539
Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular...
4.
DeTomaso D, Yosef N
Cell Syst
. 2021 May;
12(5):446-456.e9.
PMID: 33951459
Two fundamental aims that emerge when analyzing single-cell RNA-seq data are identifying which genes vary in an informative manner and determining how these genes organize into modules. Here, we propose...
5.
DeTomaso D, Jones M, Subramaniam M, Ashuach T, Ye C, Yosef N
Nat Commun
. 2019 Sep;
10(1):4376.
PMID: 31558714
We present Vision, a tool for annotating the sources of variation in single cell RNA-seq data in an automated and scalable manner. Vision operates directly on the manifold of cell-cell...
6.
Cole M, Risso D, Wagner A, DeTomaso D, Ngai J, Purdom E, et al.
Cell Syst
. 2019 Apr;
8(4):315-328.e8.
PMID: 31022373
Systematic measurement biases make normalization an essential step in single-cell RNA sequencing (scRNA-seq) analysis. There may be multiple competing considerations behind the assessment of normalization performance, of which some may...
7.
DeTomaso D, Yosef N
BMC Bioinformatics
. 2016 Aug;
17(1):315.
PMID: 27553427
Background: A key challenge in the emerging field of single-cell RNA-Seq is to characterize phenotypic diversity between cells and visualize this information in an informative manner. A common technique when...
8.
Kohnz R, Roberts L, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, et al.
ACS Chem Biol
. 2016 Jul;
11(8):2131-9.
PMID: 27380425
Many mechanisms have been proposed for how heightened aerobic glycolytic metabolism fuels cancer pathogenicity, but there are still many unexplored pathways. Here, we have performed metabolomic profiling to map glucose...