David Darling
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Explore the profile of David Darling including associated specialties, affiliations and a list of published articles.
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25
Citations
431
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Recent Articles
11.
Kavalieris L, OSullivan P, Frampton C, Guilford P, Darling D, Jacobson E, et al.
J Urol
. 2016 Dec;
197(6):1419-1426.
PMID: 27986532
Purpose: Urothelial carcinoma is associated with a high rate of recurrence. Guidelines recommend rigorous, regular surveillance programs that are invasive and expensive. This study describes a noninvasive urine test with...
12.
Breton A, Theodorou A, Aktuna S, Sonzogni L, Darling D, Chan L, et al.
Br J Haematol
. 2016 Jul;
175(3):525-530.
PMID: 27434206
In 1993, we described an English family with beta-thalassaemia that was not linked to the beta-globin locus. Whole genome sequence analyses revealed potential causative mutations in 15 different genes, of...
13.
Alkhatabi H, McLornan D, Kulasekararaj A, Malik F, Seidl T, Darling D, et al.
Oncotarget
. 2016 Jul;
7(30):47875-47890.
PMID: 27374104
We investigated the functional consequences following deletion of a microRNA (miR) termed miR-595 which resides on chromosome 7q and is localised within one of the commonly deleted regions identified for...
14.
Dick E, Matsa E, Young L, Darling D, Denning C
Nat Protoc
. 2011 Jun;
6(6):701-14.
PMID: 21637193
The protocols described here address methods used in two crucial stages in the retroviral reprogramming of somatic cells to produce human induced pluripotent stem cell (hiPSC) lines. The first is...
15.
Dick E, Matsa E, Bispham J, Reza M, Guglieri M, Staniforth A, et al.
Stem Cell Res
. 2010 Nov;
6(2):158-67.
PMID: 21095172
There are two critical stages in the retroviral reprogramming of somatic cells to produce human induced pluripotent stem cell (hiPSC) lines. One is the production of high titer virus required...
16.
Chen R, Folarin N, Ho V, McNally D, Darling D, Farzaneh F, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2010 Jul;
878(22):1939-45.
PMID: 20599176
Desthiobiotin-tagged lentiviral vectors have been metabolically produced by DBL producer cells in a 7,8-diaminopelargonic acid (7-DAPA) dependent manner for envelope independent, single-step affinity purification. 7-DAPA, which has little or no...
17.
Ingram W, Chan L, Guven H, Darling D, Kordasti S, Hardwick N, et al.
Br J Haematol
. 2009 Apr;
145(6):749-60.
PMID: 19388935
Immunotherapeutic strategies may promote T and/or natural killer (NK) cell cytotoxicity. NK cells have the potential to exert a powerful anti-leukaemia effect, as demonstrated by studies of allogeneic transplantation. We...
18.
Pickard M, Darling D, Farzaneh F, Williams G
J Androl
. 2008 Nov;
30(3):248-58.
PMID: 19023142
Because apoptotic evasion is a central feature of prostate cancer, there is an urgent need for increased understanding of the key regulatory molecules that control the life/death decision of prostate...
19.
Wells J, Cowled C, Darling D, Guinn B, Farzaneh F, Noble A, et al.
Cancer Immunol Immunother
. 2007 May;
56(12):1861-73.
PMID: 17487489
Background: Alloreactive T-cell responses are known to result in the production of large amounts of proinflammatory cytokines capable of activating and maturing dendritic cells (DC). However, it is unclear whether...
20.
Kordasti S, Ingram W, Hayden J, Darling D, Barber L, Afzali B, et al.
Blood
. 2007 Apr;
110(3):847-50.
PMID: 17412885
Foxp3+ regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their expansion...