David Darling
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Explore the profile of David Darling including associated specialties, affiliations and a list of published articles.
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25
Citations
431
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Recent Articles
1.
Regeneration linked miRNA modify tumor phenotype and can enforce multi-lineage growth arrest in vivo
Salehi S, Tavabie O, Villanueva A, Watson J, Darling D, Quaglia A, et al.
Sci Rep
. 2021 May;
11(1):10538.
PMID: 34006907
Regulated cell proliferation is an effector mechanism of regeneration, whilst dysregulated cell proliferation is a feature of cancer. We have previously identified microRNA (miRNA) that regulate successful and failed human...
2.
Woldu S, Ng C, Loo R, Slezak J, Jacobsen S, Tan W, et al.
J Urol
. 2020 Dec;
205(5):1387-1393.
PMID: 33356483
Purpose: Microhematuria is a prevalent condition and the American Urological Association has developed a new risk-stratified approach for the evaluation of patients with microhematuria. Our objective was to provide the...
3.
Lough T, Luo Q, OSullivan P, Chemasle C, Stotzer M, Suttie J, et al.
Oncol Ther
. 2020 Jul;
6(1):73-85.
PMID: 32700139
Introduction: International guidelines advocate regular surveillance of patients following urothelial carcinoma (UC). A validated molecular diagnostic non-invasive urine test, Cxbladder Monitor, correctly identifies patients with a UC history who have...
4.
Mekkaoui L, Parekh F, Kotsopoulou E, Darling D, Dickson G, Cheung G, et al.
Mol Ther Methods Clin Dev
. 2018 Dec;
11:155-165.
PMID: 30547049
Lentiviral vectors (LVs) have recently witnessed an increasing demand in research and clinical applications. Their current purification processes represent the main bottleneck in their widespread use, as the methods used...
5.
Lim S, Ioannou N, Ramsay A, Darling D, Gaken J, Mufti G
J Leukoc Biol
. 2018 Apr;
103(5):855-866.
PMID: 29656550
MicroRNAs are short endogenous noncoding RNAs that play pivotal roles in a diverse range of cellular processes. The miR-181 family is important in T cell development, proliferation, and activation. In...
6.
Lough T, Luo Q, Luxmanan C, Anderson A, Suttie J, OSullivan P, et al.
BMC Urol
. 2018 Mar;
18(1):18.
PMID: 29523118
Background: The non-invasive Cxbladder urine test system has demonstrated clinical utility in ruling out urothelial carcinoma (UC) in patients with asymptomatic microscopic hematuria (AMH), suggesting that the number of invasive...
7.
Kizilors A, Pickard M, Schulte C, Yacqub-Usman K, McCarthy N, Gan S, et al.
Biosci Rep
. 2017 Jul;
37(4).
PMID: 28754805
The E3 ubiquitin ligase RNF168 is a ring finger protein that has previously been identified to play an important regulatory role in the repair of double-strand DNA breaks. In the...
8.
Lotan Y, OSullivan P, Raman J, Shariat S, Kavalieris L, Frampton C, et al.
Urol Oncol
. 2017 Apr;
35(8):531.e15-531.e22.
PMID: 28366272
Objective: Patients with urothelial carcinoma (UC) undergo rigorous surveillance for recurrence. Noninvasive urine tests are not currently recommended by guideline panels owing to insufficient clinical benefit. The objective of this...
9.
Darling D, Luxmanan C, OSullivan P, Lough T, Suttie J
Adv Ther
. 2017 Mar;
34(5):1087-1096.
PMID: 28341930
Introduction: This study aimed to demonstrate the clinical utility of non-invasive multigene Cxbladder urine tests in reducing the overall number of diagnostic tests and invasive procedures used in the clinical...
10.
Gaymes T, Mohamedali A, Eiliazadeh A, Darling D, Mufti G
Cancer Res
. 2017 Jan;
77(7):1697-1708.
PMID: 28108507
Acquired copy neutral LOH (CN-LOH) is a frequent occurrence in myeloid malignancies and is often associated with resistance to standard therapeutic modalities and poor survival. Here, we show that constitutive...