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David D Arrington

Explore the profile of David D Arrington including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 210
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Recent Articles
1.
Covington M, Arrington D, Schnellmann R
Am J Physiol Renal Physiol . 2009 Jan; 296(3):F478-86. PMID: 19144693
Aging is associated with abnormalities in kidney function, but the exact mechanisms are unknown. We examined calpains 1, 2, and 10 protein levels in kidneys from rats, mice, and humans...
2.
Rasbach K, Arrington D, Odejinmi S, Giguere C, Beeson C, Schnellmann R
J Med Chem . 2008 Dec; 52(1):181-8. PMID: 19072163
Calpain 10 has been localized to the mitochondria and is a key mediator of Ca(2+) induced mitochondrial dysfunction. A peptide screen followed by a series of modifications identified the homodisulfide...
3.
Arrington D, Schnellmann R
Am J Physiol Cell Physiol . 2007 Dec; 294(2):C641-50. PMID: 18094145
Oxygen-regulated protein 150 (ORP150) is an inducible endoplasmic reticulum (ER) chaperone molecule that is upregulated after numerous cellular insults and has a cytoprotective role in renal, neural, and cardiac models...
4.
Arrington D, Van Vleet T, Schnellmann R
Am J Physiol Cell Physiol . 2006 Jun; 291(6):C1159-71. PMID: 16790502
Calpains, Ca(2+)-activated cysteine proteases, are cytosolic enzymes implicated in numerous cellular functions and pathologies. We identified a mitochondrial Ca(2+)-inducible protease that hydrolyzed a calpain substrate (SLLVY-AMC) and was inhibited by...
5.
Degenhardt T, Alderson N, Arrington D, Beattie R, Basgen J, Steffes M, et al.
Kidney Int . 2002 Feb; 61(3):939-50. PMID: 11849448
Background: Nonenzymatic reactions between sugars or lipids and protein and formation of advanced glycation and lipoxidation end products (AGE/ALEs) contribute to the chemical modification and cross-linking of tissue proteins with...