David Chereau
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Explore the profile of David Chereau including associated specialties, affiliations and a list of published articles.
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12
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684
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Recent Articles
1.
Levitan K, Chereau D, Cohen S, Knowles T, Dobson C, Fink A, et al.
J Mol Biol
. 2011 Jun;
411(2):329-33.
PMID: 21689664
α-Synuclein (α-syn) is the major component of filamentous Lewy bodies found in the brains of patients diagnosed with Parkinson's disease (PD). Recent studies demonstrate that, in addition to the wild-type...
2.
Neitz R, Konradi A, Sham H, Zmolek W, Wong K, Qin A, et al.
Bioorg Med Chem Lett
. 2011 May;
21(12):3726-9.
PMID: 21570836
In this Letter, we describe the evolution of selective JNK3 inhibitors from 1, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs. Strong SAR was found...
3.
Probst G, Bowers S, Sealy J, Truong A, Hom R, Galemmo Jr R, et al.
Bioorg Med Chem Lett
. 2010 Nov;
21(1):315-9.
PMID: 21112785
In this Letter, we describe the discovery of selective JNK2 and JNK3 inhibitors, such as 10, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs, p38α...
4.
Shvetsov A, Berkane E, Chereau D, Dominguez R, Reisler E
Cell Motil Cytoskeleton
. 2008 Dec;
66(2):90-8.
PMID: 19089942
Cortactin is an F-actin- and Arp2/3 complex-binding protein, implicated in the regulation of cytoskeleton dynamics and cortical actin-assembly. The actin-binding domain of cortactin consists of a 6.5 tandem repeat of...
5.
Inglis K, Chereau D, Brigham E, Chiou S, Schobel S, Frigon N, et al.
J Biol Chem
. 2008 Nov;
284(5):2598-2602.
PMID: 19004816
Several neurological diseases, including Parkinson disease and dementia with Lewy bodies, are characterized by the accumulation of alpha-synuclein phosphorylated at Ser-129 (p-Ser-129). The kinase or kinases responsible for this phosphorylation...
6.
Chereau D, Boczkowska M, Skwarek-Maruszewska A, Fujiwara I, Hayes D, Rebowski G, et al.
Science
. 2008 Apr;
320(5873):239-43.
PMID: 18403713
Initiation of actin polymerization in cells requires nucleation factors. Here we describe an actin-binding protein, leiomodin, that acted as a strong filament nucleator in muscle cells. Leiomodin shared two actin-binding...
7.
Lee S, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R
Structure
. 2007 Feb;
15(2):145-55.
PMID: 17292833
The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal WASP-homology domain 2 (WH2)....
8.
Pant K, Chereau D, Hatch V, Dominguez R, Lehman W
J Mol Biol
. 2006 May;
359(4):840-7.
PMID: 16697006
Cortactin and WASP activate Arp2/3-mediated actin filament nucleation and branching. However, different mechanisms underlie activation by the two proteins, which rely on distinct actin-binding modules and modes of binding to...
9.
Chereau D, Dominguez R
J Struct Biol
. 2006 May;
155(2):195-201.
PMID: 16684607
The Ena/VASP and WASP family of proteins play distinct roles in actin cytoskeleton remodeling. Ena/VASP is linked to actin filament elongation, whereas WASP plays a role in filament nucleation and...
10.
Chereau D, Kerff F, Graceffa P, Grabarek Z, Langsetmo K, Dominguez R
Proc Natl Acad Sci U S A
. 2005 Nov;
102(46):16644-9.
PMID: 16275905
Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) is a small and widespread actin-binding motif. In the WASP family, WH2 plays a role in filament nucleation by Arp2/3 complex. Here we...