David C Nickle
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Explore the profile of David C Nickle including associated specialties, affiliations and a list of published articles.
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83
Citations
4698
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Recent Articles
1.
El-Husseini Z, Karp T, Lan A, Gillett T, Qi C, Khalenkow D, et al.
Am J Respir Cell Mol Biol
. 2025 Jan;
PMID: 39836087
Asthma is a genetically complex inflammatory airway disease associated with over 200 Single nucleotide polymorphisms (SNPs). However, the functional effects of many asthma-associated SNPs in lung and airway epithelial samples...
2.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2024 Apr;
56(5):1032-1033.
PMID: 38641645
No abstract available.
3.
Valette K, Li Z, Bon-Baret V, Chignon A, Berube J, Eslami A, et al.
Commun Biol
. 2021 Jun;
4(1):700.
PMID: 34103634
To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on a broad asthma definition (n = 56,167 asthma cases and 352,255 controls)....
4.
Zhao H, Nickle D, Zeng Z, Law P, Wilcox M, Chen L, et al.
Infect Dis Ther
. 2021 Mar;
10(2):853-870.
PMID: 33751421
Introduction: Clostridioides (Clostridium) difficile infection, the leading cause of healthcare-associated diarrhea, represents a significant burden on global healthcare systems. Despite being a global issue, information on C. difficile from a...
5.
Guerrina N, Traboulsi H, de Souza A, Bosse Y, Thatcher T, Robichaud A, et al.
FASEB J
. 2021 Feb;
35(3):e21376.
PMID: 33605487
Emphysema, a component of chronic obstructive pulmonary disease (COPD), is characterized by irreversible alveolar destruction that results in a progressive decline in lung function. This alveolar destruction is caused by...
6.
Florez-Sampedro L, Brandsma C, de Vries M, Timens W, Bults R, Vermeulen C, et al.
Sci Rep
. 2020 Oct;
10(1):16980.
PMID: 33046825
Macrophage migration inhibitory factor (MIF) is a cytokine found to be associated with chronic obstructive pulmonary disease (COPD). However, there is no consensus on how MIF levels differ in COPD...
7.
Ketelaar M, Portelli M, Dijk F, Shrine N, Faiz A, Vermeulen C, et al.
J Allergy Clin Immunol
. 2020 May;
147(1):144-157.
PMID: 32442646
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33...
8.
Ji X, Mukherjee S, Landi M, Bosse Y, Joubert P, Zhu D, et al.
Nat Commun
. 2020 May;
11(1):2220.
PMID: 32393777
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples....
9.
Portelli M, Dijk F, Ketelaar M, Shrine N, Hankinson J, Bhaker S, et al.
JCI Insight
. 2020 Apr;
5(8).
PMID: 32324168
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying...
10.
Allen R, Guillen-Guio B, Oldham J, Ma S, Dressen A, Paynton M, et al.
Am J Respir Crit Care Med
. 2019 Nov;
201(5):564-574.
PMID: 31710517
Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide...