David C Nickle
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Explore the profile of David C Nickle including associated specialties, affiliations and a list of published articles.
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83
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4698
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Recent Articles
11.
van den Berge M, Brandsma C, Faiz A, de Vries M, Rathnayake S, Pare P, et al.
Eur Respir J
. 2019 Jun;
54(1).
PMID: 31164434
No abstract available.
12.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2019 May;
51(6):1067.
PMID: 31110354
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
13.
Shrine N, Guyatt A, Erzurumluoglu A, Jackson V, Hobbs B, Melbourne C, et al.
Nat Genet
. 2019 Feb;
51(3):481-493.
PMID: 30804560
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define...
14.
Shrine N, Portelli M, John C, Artigas M, Bennett N, Hall R, et al.
Lancet Respir Med
. 2018 Dec;
7(1):20-34.
PMID: 30552067
Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types...
15.
Ji X, Bosse Y, Landi M, Gui J, Xiao X, Qian D, et al.
Nat Commun
. 2018 Aug;
9(1):3221.
PMID: 30104567
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung...
16.
Obeidat M, Dvorkin-Gheva A, Li X, Bosse Y, Brandsma C, Nickle D, et al.
Sci Rep
. 2018 Aug;
8(1):11881.
PMID: 30089872
Genome-wide mRNA profiling in lung tissue from human and animal models can provide novel insights into the pathogenesis of chronic obstructive pulmonary disease (COPD). While 6 months of smoke exposure...
17.
Wyss A, Sofer T, Lee M, Terzikhan N, Nguyen J, Lahousse L, et al.
Nat Commun
. 2018 Aug;
9(1):2976.
PMID: 30061609
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed...
18.
Nedeljkovic I, Carnero-Montoro E, Lahousse L, van der Plaat D, de Jong K, Vonk J, et al.
Eur J Hum Genet
. 2018 Feb;
26(5):709-722.
PMID: 29422661
Chronic obstructive pulmonary disease (COPD) is a major health burden in adults and cigarette smoking is considered the most important environmental risk factor of COPD. Chromosome 15q25.1 locus is associated...
19.
de Vries M, Faiz A, Woldhuis R, Postma D, de Jong T, Sin D, et al.
Thorax
. 2017 Dec;
PMID: 29212667
Introduction: COPD is a chronic, progressive, inflammatory disease of the lungs and the third leading cause of death worldwide. The current knowledge of the pathophysiology of COPD is limited and...
20.
Obeidat M, Li X, Burgess S, Zhou G, Fishbane N, Hansel N, et al.
Eur Respir J
. 2017 Dec;
50(5).
PMID: 29191953
Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with...