David C Hughes
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Explore the profile of David C Hughes including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Bruno N, Nwachukwu J, Hughes D, Srinivasan S, Hawkins R, Sturgill D, et al.
FASEB J
. 2021 Nov;
35(12):e21999.
PMID: 34748223
The Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators drive Creb1-mediated transcription effects on metabolism in many tissues, but the in vivo effects of Crtc2/Creb1 transcription on skeletal muscle metabolism...
12.
Baehr L, Hughes D, Lynch S, Van Haver D, Mendes Maia T, Marshall A, et al.
Function (Oxf)
. 2021 Jun;
2(4):zqab029.
PMID: 34179788
MuRF1 (TRIM63) is a muscle-specific E3 ubiquitin ligase and component of the ubiquitin proteasome system. MuRF1 is transcriptionally upregulated under conditions that cause muscle loss, in both rodents and humans,...
13.
Wallace M, Aguirre N, Marcotte G, Marshall A, Baehr L, Hughes D, et al.
Aging Cell
. 2021 Mar;
20(4):e13322.
PMID: 33675103
The causes of the decline in skeletal muscle mass and function with age, known as sarcopenia, are poorly understood. Nutrition (calorie restriction) interventions impact many cellular processes and increase lifespan...
14.
Hughes D, Turner D, Baehr L, Seaborne R, Viggars M, Jarvis J, et al.
Am J Physiol Cell Physiol
. 2020 Oct;
320(1):C45-C56.
PMID: 33052072
UBR5 is an E3 ubiquitin ligase positively associated with anabolism, hypertrophy, and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle...
15.
McAuley A, Hughes D, Tsaprouni L, Varley I, Suraci B, Roos T, et al.
J Sports Sci
. 2020 Aug;
39(2):200-211.
PMID: 32856541
The aim of this review was to assess the association of R577X and I/D polymorphisms with athlete status in football and determine which allele and/or genotypes are most likely to...
16.
Elliott B, Hayes L, Hughes D, Burtscher M
Front Physiol
. 2020 Aug;
11:883.
PMID: 32848842
No abstract available.
17.
Hughes D, Baehr L, Driscoll J, Lynch S, Waddell D, Bodine S
Am J Physiol Cell Physiol
. 2020 Aug;
319(4):C700-C719.
PMID: 32783651
Muscle-specific E3 ubiquitin ligases have been identified in muscle atrophy-inducing conditions. The purpose of the current study was to explore the functional role of F-box and leucine-rich protein 22 (Fbxl22),...
18.
Huang X, Li Z, De Guzman E, Robinson P, Gensler L, Ward M, et al.
Invest Ophthalmol Vis Sci
. 2020 Jun;
61(6):3.
PMID: 32492107
Purpose: Acute anterior uveitis (AAU) is a common intraocular inflammatory disease. AAU occurs in 30% to 50% of patients with ankylosing spondylitis (AS), and both conditions are strongly associated with...
19.
McAuley A, Hughes D, Tsaprouni L, Varley I, Suraci B, Roos T, et al.
Eur J Sport Sci
. 2020 May;
21(5):714-752.
PMID: 32466725
Genetic variation is responsible for a large amount of the inter-individual performance disparities seen in sport. As such, in the last ten years genetic association studies have become more common;...
20.
Seaborne R, Hughes D, Turner D, Owens D, Baehr L, Gorski P, et al.
J Physiol
. 2019 May;
597(14):3727-3749.
PMID: 31093990
Key Points: We have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle hypertrophy, where its gene expression...