David Brocks
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Explore the profile of David Brocks including associated specialties, affiliations and a list of published articles.
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18
Citations
1538
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Recent Articles
11.
Oakes C, Seifert M, Assenov Y, Gu L, Przekopowitz M, Ruppert A, et al.
Nat Genet
. 2016 Jan;
48(3):253-64.
PMID: 26780610
Charting differences between tumors and normal tissue is a mainstay of cancer research. However, clonal tumor expansion from complex normal tissue architectures potentially obscures cancer-specific events, including divergent epigenetic patterns....
12.
Brocks D
Clin Epigenetics
. 2015 Sep;
7:94.
PMID: 26357527
Scientific data has been transformed into music in order to raise awareness in the non-scientific community. While the general public is nowadays familiar with the genetic code, there is still...
13.
Walter D, Lier A, Geiselhart A, Thalheimer F, Huntscha S, Sobotta M, et al.
Nature
. 2015 Feb;
520(7548):549-52.
PMID: 25707806
Haematopoietic stem cells (HSCs) are responsible for the lifelong production of blood cells. The accumulation of DNA damage in HSCs is a hallmark of ageing and is probably a major...
14.
Lipka D, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, et al.
Cell Cycle
. 2014 Dec;
13(22):3476-87.
PMID: 25483069
Epigenetic alterations during cellular differentiation are a key molecular mechanism which both instructs and reinforces the process of lineage commitment. Within the haematopoietic system, progressive changes in the DNA methylome...
15.
Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka D, Reyes A, Wang Q, et al.
Cell Stem Cell
. 2014 Aug;
15(4):507-522.
PMID: 25158935
In this study, we present integrated quantitative proteome, transcriptome, and methylome analyses of hematopoietic stem cells (HSCs) and four multipotent progenitor (MPP) populations. From the characterization of more than 6,000...
16.
Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C, et al.
Cell Rep
. 2014 Jul;
8(3):798-806.
PMID: 25066126
Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we show that the...
17.
Bierhoff H, Dammert M, Brocks D, Dambacher S, Schotta G, Grummt I
Mol Cell
. 2014 Apr;
54(4):675-82.
PMID: 24768537
A complex network of regulatory pathways links transcription to cell growth and proliferation. Here we show that cellular quiescence alters chromatin structure by promoting trimethylation of histone H4 at lysine...
18.
Oakes C, Claus R, Gu L, Assenov Y, Hullein J, Zucknick M, et al.
Cancer Discov
. 2013 Dec;
4(3):348-61.
PMID: 24356097
Although clonal selection by genetic driver aberrations in cancer is well documented, the ability of epigenetic alterations to promote tumor evolution is undefined. We used 450k arrays and next-generation sequencing...