Dieter Weichenhan
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Explore the profile of Dieter Weichenhan including associated specialties, affiliations and a list of published articles.
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109
Citations
3916
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Recent Articles
1.
Gehrs S, Jakab M, Gutjahr E, Gu Z, Weichenhan D, Mallm J, et al.
Dev Cell
. 2025 Jan;
PMID: 39814015
The labyrinthian fetoplacental capillary network is vital for proper nourishment of the developing embryo. Dysfunction of the maternal-fetal circulation is a primary cause of placental insufficiency. Here, we show that...
2.
Weichenhan D, Riedel A, Sollier E, Toprak U, Hey J, Breuer K, et al.
Blood Adv
. 2024 Aug;
8(19):5100-5111.
PMID: 39121370
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and...
3.
Bakr A, Della Corte G, Veselinov O, Kelekci S, Chen M, Lin Y, et al.
Nucleic Acids Res
. 2024 Apr;
52(10):5698-5719.
PMID: 38587186
AT-rich interaction domain protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. Loss of ARID1A leads to DNA repair defects. Here, we show...
4.
Schopf J, Uhrig S, Heilig C, Lee K, Walther T, Carazzato A, et al.
Nat Commun
. 2024 Jan;
15(1):51.
PMID: 38168093
Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective...
5.
Schmutz M, Zucknick M, Schlenk R, Mertens D, Benner A, Weichenhan D, et al.
Clin Epigenetics
. 2023 Oct;
15(1):171.
PMID: 37885041
Background: Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from...
6.
Waraky A, Ostlund A, Nilsson T, Weichenhan D, Lutsik P, Bahr M, et al.
Haematologica
. 2023 Jun;
109(3):725-739.
PMID: 37317878
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such as AML with translocation t(7;12)(q36;p13) leading to an MNX1::ETV6 fusion along with high expression of MNX1. We...
7.
Schwartz U, Llamazares Prada M, Pohl S, Richter M, Tamas R, Schuler M, et al.
EMBO J
. 2023 May;
42(12):e111272.
PMID: 37143403
Patients with chronic obstructive pulmonary disease (COPD) are still waiting for curative treatments. Considering its environmental cause, we hypothesized that COPD will be associated with altered epigenetic signaling in lung...
8.
Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking
Weichenhan D, Riedel A, Meinen C, Basic A, Toth R, Bahr M, et al.
Leukemia
. 2023 Mar;
37(5):1147-1150.
PMID: 36949154
No abstract available.
9.
Oeing C, Pepin M, Saul K, Agircan A, Assenov Y, Merkel T, et al.
Basic Res Cardiol
. 2023 Mar;
118(1):9.
PMID: 36939901
Precision-based molecular phenotyping of heart failure must overcome limited access to cardiac tissue. Although epigenetic alterations have been found to underlie pathological cardiac gene dysregulation, the clinical utility of myocardial...
10.
Thurmann L, Klos M, Mackowiak S, Bieg M, Bauer T, Ishaque N, et al.
Allergy
. 2023 Jan;
78(6):1489-1506.
PMID: 36704932
Background: Childhood asthma is a result of a complex interaction of genetic and environmental components causing epigenetic and immune dysregulation, airway inflammation and impaired lung function. Although different microarray based...