David Brealey
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Explore the profile of David Brealey including associated specialties, affiliations and a list of published articles.
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70
Citations
2022
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Recent Articles
1.
Antcliffe D, Peronnet E, Pene F, Stralin K, Brealey D, Blein S, et al.
Crit Care
. 2025 Mar;
29(1):98.
PMID: 40033354
Background: Sepsis gene-expression sub-phenotypes with prognostic and theranostic potential have been discovered. These have been identified retrospectively and have not been translated to methods that could be deployed at the...
2.
Enne V, Stirling S, Barber J, High J, Russell C, Brealey D, et al.
Intensive Care Med
. 2025 Feb;
51(2):272-286.
PMID: 39961847
Purpose: INHALE investigated the impact of seeking pathogens by PCR on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia (HAP and VAP). Methods: This pragmatic multicentre, open-label RCT...
3.
Stewart S, Pandolfo A, Jani Y, Moon Z, Brealey D, Enne V, et al.
Antimicrob Agents Chemother
. 2025 Feb;
69(3):e0115624.
PMID: 39907301
Rapid molecular diagnostic tests improve antimicrobial stewardship (AMS) by facilitating earlier refinement of antimicrobial therapy. The INHALE trial tested the application of the BioFire FilmArray Pneumonia Panel (Pneumonia Panel) for...
4.
Gutierrez Del Arroyo A, Abbott T, Patel A, Begum S, Dias P, Brealey D, et al.
Br J Anaesth
. 2024 Dec;
PMID: 39709293
Background: Hypertension therapy in older adults is often suboptimal, in part because of inadequate suppression of the renin-angiotensin-aldosterone system (RAAS). We hypothesised that distinct endotypes of RAAS activation before noncardiac...
5.
Zimmermann T, Brealey D, Singer M
Crit Care Med
. 2024 Dec;
53(3):e543-e547.
PMID: 39692567
No abstract available.
6.
Dark P, Hossain A, McAuley D, Brealey D, Carlson G, Clayton J, et al.
JAMA
. 2024 Dec;
333(8):682-693.
PMID: 39652885
Importance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect...
7.
Terrett A, Van Loo M, Sundararajan K, Brealey D, Singer M, Manson J, et al.
JBI Evid Synth
. 2024 Sep;
23(1):158-164.
PMID: 39295473
Objective: The objective of this review is to identify immunological pathways and markers of severity of illness associated with clinical outcomes that may represent potential therapeutic targets in the management...
8.
Arulkumaran N, Thomas M, Stubbs M, Prasanna N, Subhan M, Singh D, et al.
Sci Rep
. 2024 Jul;
14(1):16876.
PMID: 39043682
COVID-19 disease is associated with a hyperinflammatory, pro-thrombotic state and a high mortality. Our primary objective was to assess the change in inflammatory and thrombotic markers associated with PEX, and...
9.
Zimmermann T, Brealey D, Singer M
Intensive Care Med
. 2024 May;
50(6):957-959.
PMID: 38695925
No abstract available.
10.
Early dynamic changes to monocytes following major surgery are associated with subsequent infections
Snow T, Waller A, Loye R, Ryckaert F, Cesar A, Saleem N, et al.
Front Immunol
. 2024 Apr;
15:1352556.
PMID: 38655251
Background: Post-operative infections are a common cause of morbidity following major surgery. Little is understood about how major surgery perturbs immune function leading to heightened risk of subsequent infection. Through...