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David Brealey

Explore the profile of David Brealey including associated specialties, affiliations and a list of published articles. Areas
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Articles 70
Citations 2022
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Recent Articles
11.
Pirani T, Wilson A, Brealey D, Low R, ONeill S, Le J, et al.
Br J Anaesth . 2024 Mar; 132(5):1004-1006. PMID: 38521658
No abstract available.
12.
Gutierrez Del Arroyo A, Patel A, Abbott T, Begum S, Dias P, Somanath S, et al.
Br J Anaesth . 2024 Feb; 132(5):857-866. PMID: 38341283
Background: Patients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml) experience more complications after noncardiac surgery. Individuals prescribed renin-angiotensin system (RAS) inhibitors for cardiometabolic disease are...
13.
Snow T, Serisier A, Brealey D, Singer M, Arulkumaran N
Intensive Care Med Exp . 2024 Jan; 12(1):3. PMID: 38206543
No abstract available.
14.
Dushianthan A, Clark H, Brealey D, Pratt D, Fink J, Madsen J, et al.
Sci Rep . 2023 Nov; 13(1):20946. PMID: 38017061
SARS-CoV-2 directly targets alveolar epithelial cells and can lead to surfactant deficiency. Early reports suggested surfactant replacement may be effective in improving outcomes. The aim of the study to assess...
15.
Stewart S, Pandolfo A, Moon Z, Jani Y, Brett S, Brealey D, et al.
J Antimicrob Chemother . 2023 Nov; 79(1):123-127. PMID: 37970680
Background: Molecular diagnostic tests may improve antibiotic prescribing by enabling earlier tailoring of antimicrobial therapy. However, clinicians' trust and acceptance of these tests will determine their application in practice. Objectives:...
16.
Ackland G, Patel A, Abbott T, Begum S, Dias P, Crane D, et al.
Eur Heart J . 2023 Nov; 45(13):1146-1155. PMID: 37935833
Background And Aims: Haemodynamic instability is associated with peri-operative myocardial injury, particularly in patients receiving renin-angiotensin system (RAS) inhibitors (angiotensin-converting-enzyme inhibitors/angiotensin II receptor blockers). Whether stopping RAS inhibitors to minimise...
17.
Coughlan C, Jager H, Brealey D, Carletti F, Hyare H, Pattnaik R, et al.
Clin Infect Dis . 2023 Oct; 78(2):457-460. PMID: 37897407
Cerebral malaria is an important cause of mortality and neurodisability in endemic regions. We show magnetic resonance imaging (MRI) features suggestive of cytotoxic and vasogenic cerebral edema followed by microhemorrhages...
18.
Gorman E, Rynne J, Gardiner H, Rostron A, Bannard-Smith J, Bentley A, et al.
Am J Respir Crit Care Med . 2023 May; 208(3):256-269. PMID: 37154608
Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in coronavirus disease (COVID-19)-related acute respiratory distress syndrome (ARDS). We investigated the safety and efficacy of ORBCEL-C (CD362 [cluster of differentiation...
19.
Wilson M, Asselbergs F, Miguel R, Brealey D, Harris S
BMJ Open . 2022 Sep; 12(9):e059995. PMID: 36123103
Introduction: Many routinely administered treatments lack evidence as to their effectiveness. When treatments lack evidence, patients receive varying care based on the preferences of clinicians. Standard randomised controlled trials are...
20.
Lukaszewski R, Jones H, Gersuk V, Russell P, Simpson A, Brealey D, et al.
Intensive Care Med . 2022 Jul; 48(9):1133-1143. PMID: 35831640
Purpose: Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to identify infection and impending organ dysfunction before the onset...