David Beare
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Explore the profile of David Beare including associated specialties, affiliations and a list of published articles.
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11
Citations
7817
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Recent Articles
1.
Sondka Z, Dhir N, Carvalho-Silva D, Jupe S, Madhumita , McLaren K, et al.
Nucleic Acids Res
. 2024 Jan;
52(D1):D1210-D1217.
PMID: 38183204
The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer.sanger.ac.uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in cancer, supported by a comprehensive suite of tools for interpreting genomic...
2.
Forbes S, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, et al.
Nucleic Acids Res
. 2016 Dec;
45(D1):D777-D783.
PMID: 27899578
COSMIC, the Catalogue of Somatic Mutations in Cancer (http://cancer.sanger.ac.uk) is a high-resolution resource for exploring targets and trends in the genetics of human cancer. Currently the broadest database of mutations...
3.
Forbes S, Beare D, Gunasekaran P, Leung K, Bindal N, Boutselakis H, et al.
Nucleic Acids Res
. 2014 Oct;
43(Database issue):D805-11.
PMID: 25355519
COSMIC, the Catalogue Of Somatic Mutations In Cancer (http://cancer.sanger.ac.uk) is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer. Our latest release...
4.
Tarpey P, Behjati S, Cooke S, Van Loo P, Wedge D, Pillay N, et al.
Nat Genet
. 2013 Jun;
45(8):923-6.
PMID: 23770606
Chondrosarcoma is a heterogeneous collection of malignant bone tumors and is the second most common primary malignancy of bone after osteosarcoma. Recent work has identified frequent, recurrent mutations in IDH1...
5.
Stephens P, Tarpey P, Davies H, Van Loo P, Greenman C, Wedge D, et al.
Nature
. 2012 Jun;
486(7403):400-4.
PMID: 22722201
All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis, and the remainder...
6.
Shepherd R, Forbes S, Beare D, Bamford S, Cole C, Ward S, et al.
Database (Oxford)
. 2011 May;
2011:bar018.
PMID: 21609966
Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just...
7.
Stephens P, Greenman C, Fu B, Yang F, Bignell G, Mudie L, et al.
Cell
. 2011 Jan;
144(1):27-40.
PMID: 21215367
Cancer is driven by somatically acquired point mutations and chromosomal rearrangements, conventionally thought to accumulate gradually over time. Using next-generation sequencing, we characterize a phenomenon, which we term chromothripsis, whereby...
8.
Forbes S, Bindal N, Bamford S, Cole C, Kok C, Beare D, et al.
Nucleic Acids Res
. 2010 Oct;
39(Database issue):D945-50.
PMID: 20952405
COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136,000 coding mutations in almost 542,000 tumour samples; of the 18,490 genes documented,...
9.
Bignell G, Greenman C, Davies H, Butler A, Edkins S, Andrews J, et al.
Nature
. 2010 Feb;
463(7283):893-8.
PMID: 20164919
The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous deletions in cancer genomes occur over recessive cancer genes, where they can confer selective growth...
10.
Pleasance E, Stephens P, OMeara S, McBride D, Meynert A, Jones D, et al.
Nature
. 2009 Dec;
463(7278):184-90.
PMID: 20016488
Cancer is driven by mutation. Worldwide, tobacco smoking is the principal lifestyle exposure that causes cancer, exerting carcinogenicity through >60 chemicals that bind and mutate DNA. Using massively parallel sequencing...