David B Savage
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Explore the profile of David B Savage including associated specialties, affiliations and a list of published articles.
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105
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6661
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Recent Articles
1.
Mann J, Tabara L, Patel S, Pushpa P, Alvarez-Guaita A, Dong L, et al.
PLoS One
. 2024 Dec;
19(12):e0306243.
PMID: 39739772
Objective: A biallelic missense mutation in mitofusin 2 (MFN2) causes multiple symmetric lipomatosis and partial lipodystrophy, implicating disruption of mitochondrial fusion or interaction with other organelles in adipocyte differentiation, growth...
2.
Azhar M, Watson L, De Lucia Rolfe E, Ferraro M, Carr K, Worsley J, et al.
NMR Biomed
. 2024 Feb;
37(8):e5117.
PMID: 38356104
It has been shown using proton magnetic resonance spectroscopy (H MRS) that, in a group of females, whole-body insulin resistance was more closely related to accumulation of saturated intramyocellular lipid...
3.
Duan X, Savage D
FEBS Lett
. 2023 Nov;
598(10):1205-1206.
PMID: 38016936
Proteins which associate with the surface of lipid droplets are intimately involved in the regulation of the droplets. Several human inherited disorders have now been linked to loss- and, in...
4.
Ganeva I, Lim K, Boulanger J, Hoffmann P, Muriel O, Borgeaud A, et al.
Cell Rep
. 2023 Feb;
42(2):112107.
PMID: 36800289
Lipid droplets (LDs) are intracellular organelles responsible for storing surplus energy as neutral lipids. Their size and number vary enormously. In white adipocytes, LDs can reach 100 μm in diameter,...
5.
Mann J, Duan X, Patel S, Tabara L, Scurria F, Alvarez-Guaita A, et al.
Elife
. 2023 Feb;
12.
PMID: 36722855
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception,...
6.
7.
Grigoriadis D, Sackey E, Riches K, van Zanten M, Brice G, England R, et al.
PLoS One
. 2022 Oct;
17(10):e0274867.
PMID: 36227936
Lipoedema is a chronic adipose tissue disorder mainly affecting women, causing excess subcutaneous fat deposition on the lower limbs with pain and tenderness. There is often a family history of...
8.
Mosbah H, Akinci B, Araujo-Vilar D, Carrion Tudela J, Ceccarini G, Collas P, et al.
Ann Endocrinol (Paris)
. 2022 Oct;
83(6):461-468.
PMID: 36206842
Lipodystrophy syndromes are rare diseases with defects in the development or maintenance of adipose tissue, frequently leading to severe metabolic complications. They may be genetic or acquired, with variable clinical...
9.
Patel S, Haider A, Alvarez-Guaita A, Bidault G, El-Sayed Moustafa J, Guiu-Jurado E, et al.
Mol Metab
. 2022 Sep;
65:101589.
PMID: 36064109
Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with...
10.
Zhong Z, Harris J, Wilber E, Gorman S, Savage D, ORahilly S, et al.
Clin Endocrinol (Oxf)
. 2022 Aug;
97(6):755-762.
PMID: 35920656
Context: Familial partial lipodystrophy type 2 (FPLD2) results from autosomal dominant mutations in the LMNA gene, causing lack of subcutaneous fat deposition and excess ectopic fat accumulation, leading to metabolic...