David Arnott
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Explore the profile of David Arnott including associated specialties, affiliations and a list of published articles.
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56
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3266
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Recent Articles
11.
Guler G, Tindell C, Pitti R, Wilson C, Nichols K, KaiWai Cheung T, et al.
Cancer Cell
. 2017 Aug;
32(2):221-237.e13.
PMID: 28781121
Maintenance of phenotypic heterogeneity within cell populations is an evolutionarily conserved mechanism that underlies population survival upon stressful exposures. We show that the genomes of a cancer cell subpopulation that...
12.
Egan B, Yuan C, Craske M, Labhart P, Guler G, Arnott D, et al.
PLoS One
. 2016 Nov;
11(11):e0166438.
PMID: 27875550
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require...
13.
Doll S, Urisman A, Oses-Prieto J, Arnott D, Burlingame A
Mol Cell Proteomics
. 2016 Nov;
16(1):39-56.
PMID: 27834733
Glioblastoma multiformes (GBMs) are high-grade astrocytomas and the most common brain malignancies. Primary GBMs are often associated with disturbed RAS signaling, and expression of oncogenic HRAS results in a malignant...
14.
Morisaki J, Smith P, Date S, Kajihara K, Truong C, Modrusan Z, et al.
mBio
. 2016 Sep;
7(5).
PMID: 27601569
Unlabelled: The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel...
15.
Gnad F, Wallin J, Edgar K, Doll S, Arnott D, Robillard L, et al.
Proteomics
. 2016 Jun;
16(14):1992-7.
PMID: 27282143
The PI3K pathway is commonly activated in cancer. Only a few studies have attempted to explore the spectrum of phosphorylation signaling downstream of the PI3K cascade. Such insight, however, is...
16.
Gnad F, Doll S, Song K, Stokes M, Moffat J, Liu B, et al.
Proteomics
. 2016 Jun;
16(14):1998-2004.
PMID: 27273156
The RAS-RAF-MEK-ERK (MAPK) pathway is prevalently perturbed in cancer. Recent large-scale sequencing initiatives profiled thousands of tumors providing insight into alterations at the DNA and RNA levels. These efforts confirmed...
17.
Vinogradova M, Gehling V, Gustafson A, Arora S, Tindell C, Wilson C, et al.
Nat Chem Biol
. 2016 May;
12(7):531-8.
PMID: 27214401
The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs). Here we...
18.
Qu Y, Misaghi S, Newton K, Maltzman A, Izrael-Tomasevic A, Arnott D, et al.
J Exp Med
. 2016 May;
213(6):877-85.
PMID: 27139490
NLRC4 and NLRP3, of the NOD-like receptor (NLR) family of intracellular proteins, are expressed in innate immune cells and are thought to nucleate distinct inflammasome complexes that promote caspase-1 activation,...
19.
Gnad F, Doll S, Manning G, Arnott D, Zhang Z
BMC Genomics
. 2015 Jun;
16 Suppl 8:S5.
PMID: 26110843
Background: Many cancer cells show distorted epigenetic landscapes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors, allowing the discovery of somatic alterations in the epigenetic machinery and the...
20.
Maile T, Izrael-Tomasevic A, Cheung T, Guler G, Tindell C, Masselot A, et al.
Mol Cell Proteomics
. 2015 Feb;
14(4):1148-58.
PMID: 25680960
Mass spectrometry is a powerful alternative to antibody-based methods for the analysis of histone post-translational modifications (marks). A key development in this approach was the deliberate propionylation of histones to...