David A Scicchitano
Overview
Explore the profile of David A Scicchitano including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
274
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Recent Articles
1.
Ezerskyte M, Paredes J, Malvezzi S, Burns J, Margison G, Olsson M, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(18):4731-4736.
PMID: 29666243
Altered protein function due to mutagenesis plays an important role in disease development. This is perhaps most evident in tumorigenesis and the associated loss or gain of function of tumor-suppressor...
2.
Burns J, Chowdhury M, Cartularo L, Berens C, Scicchitano D
Nucleic Acids Res
. 2018 Feb;
46(7):3498-3516.
PMID: 29474673
Simple sequence repeats (SSRs) are found throughout the genome, and under some conditions can change in length over time. Germline and somatic expansions of trinucleotide repeats are associated with a...
3.
Kolbanovskiy M, Chowdhury M, Nadkarni A, Broyde S, Geacintov N, Scicchitano D, et al.
Biochemistry
. 2017 May;
56(24):3008-3018.
PMID: 28514164
The most common, oxidatively generated lesion in cellular DNA is 8-oxo-7,8-dihydroguanine, which can be oxidized further to yield highly mutagenic spiroiminodihydantoin (Sp) and 5-guanidinohydantoin (Gh) in DNA. In human cell-free...
4.
Nadkarni A, Burns J, Gandolfi A, Chowdhury M, Cartularo L, Berens C, et al.
J Biol Chem
. 2015 Nov;
291(2):848-61.
PMID: 26559971
DNA adducts derived from carcinogenic polycyclic aromatic hydrocarbons like benzo[a]pyrene (B[a]P) and benzo[c]phenanthrene (B[c]Ph) impede replication and transcription, resulting in aberrant cell division and gene expression. Global nucleotide excision repair...
5.
Burns J, Dreij K, Cartularo L, Scicchitano D
Nucleic Acids Res
. 2010 Aug;
38(22):8178-87.
PMID: 20702424
O(6)-Methylguanine (O(6)-meG), which is produced in DNA following exposure to methylating agents, instructs human RNA polymerase II to mis-insert bases opposite the lesion during transcription. In this study, we examined...
6.
Dreij K, Rhrissorrakrai K, Gunsalus K, Geacintov N, Scicchitano D
Carcinogenesis
. 2010 Apr;
31(6):1149-57.
PMID: 20382639
Cellular responses to carcinogens are typically studied in transformed cell lines, which do not reflect the physiological status of normal tissues. To address this question, we have characterized the transcriptional...
7.
Dimitri A, Burns J, Broyde S, Scicchitano D
Nucleic Acids Res
. 2008 Oct;
36(20):6459-71.
PMID: 18854351
O(6)-Methylguanine (O(6)-meG) is a major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous methylating agents. We report the results of transcription past a site-specifically modified O(6)-meG...
8.
Dimitri A, Jia L, Shafirovich V, Geacintov N, Broyde S, Scicchitano D
DNA Repair (Amst)
. 2008 Jun;
7(8):1276-88.
PMID: 18555749
Damage in transcribed DNA presents a challenge to the cell because it can partially or completely block the progression of an RNA polymerase, interfering with transcription and compromising gene expression....
9.
Dimitri A, Goodenough A, Guengerich F, Broyde S, Scicchitano D
J Mol Biol
. 2007 Nov;
375(2):353-66.
PMID: 18022639
The DNA lesion 1,N(2)-ethenoguanine (1,N(2)-epsilon G) is formed endogenously as a by-product of lipid peroxidation or by reaction with epoxides that result from the metabolism of the industrial pollutant vinyl...
10.
Perlow-Poehnelt R, Likhterov I, Wang L, Scicchitano D, Geacintov N, Broyde S
J Biol Chem
. 2006 Nov;
282(2):1397-408.
PMID: 17090533
The Y-family DNA polymerase Dpo4, from the thermophilic crenarchaeon Sulfolobus solfataricus P2, offers a valuable opportunity to investigate the effect of conformational flexibility on the bypass of bulky lesions because...