Suse Broyde
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Explore the profile of Suse Broyde including associated specialties, affiliations and a list of published articles.
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Articles
118
Citations
1933
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0
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Recent Articles
1.
Sales A, Fu I, Durandin A, Ciervo S, Lupoli T, Shafirovich V, et al.
Int J Mol Sci
. 2024 Jul;
25(14.
PMID: 39063172
The SARS-CoV-2 helicase, non-structural protein 13 (Nsp13), plays an essential role in viral replication, translocating in the 5' → 3' direction as it unwinds double-stranded RNA/DNA. We investigated the impact...
2.
Fu I, Geacintov N, Broyde S
Nucleic Acids Res
. 2023 Nov;
51(22):12261-12274.
PMID: 37933861
Ultraviolet light generates cyclobutane pyrimidine dimer (CPD) and pyrimidine 6-4 pyrimidone (6-4PP) photoproducts that cause skin malignancies if not repaired by nucleotide excision repair (NER). While the faster repair of...
3.
Sales A, Zheng V, Kenawy M, Kakembo M, Zhang L, Shafirovich V, et al.
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555294
DNA helicase unwinding activity can be inhibited by small molecules and by covalently bound DNA lesions. Little is known about the relationships between the structural features of DNA lesions and...
4.
Fu I, Mu H, Geacintov N, Broyde S
Nucleic Acids Res
. 2022 Jun;
50(12):6837-6853.
PMID: 35713557
In nucleotide excision repair (NER), the xeroderma pigmentosum D helicase (XPD) scans DNA searching for bulky lesions, stalls when encountering such damage to verify its presence, and allows repair to...
5.
Paul D, Mu H, Tavakoli A, Dai Q, Chakraborty S, He C, et al.
DNA Repair (Amst)
. 2021 Aug;
107:103194.
PMID: 34428697
Rad4/XPC recognizes diverse DNA lesions to initiate nucleotide excision repair (NER). However, NER propensities among lesions vary widely and repair-resistant lesions are persistent and thus highly mutagenic. Rad4 recognizes repair-proficient...
6.
Fu I, Geacintov N, Broyde S
DNA Repair (Amst)
. 2021 Aug;
107:103201.
PMID: 34399316
The first order of DNA packaging is the nucleosome with the DNA wrapped around the histone octamer. This leaves the nucleosomal DNA with access restrictions, which impose a significant barrier...
7.
Thomforde J, Fu I, Rodriguez F, Pujari S, Broyde S, Tretyakova N
Biochemistry
. 2021 Jun;
60(23):1797-1807.
PMID: 34080848
DNA-protein cross-links (DPCs) are unusually bulky DNA lesions that form when cellular proteins become trapped on DNA following exposure to ultraviolet light, free radicals, aldehydes, and transition metals. DPCs can...
8.
Tavakoli A, Paul D, Mu H, Kuchlyan J, Baral S, Ansari A, et al.
RSC Chem Biol
. 2021 May;
2(2):523-536.
PMID: 34041491
Biomolecular structural changes upon binding/unbinding are key to their functions. However, characterization of such dynamical processes is difficult as it requires ways to rapidly and specifically trigger the assembly/disassembly as...
9.
Paul D, Mu H, Tavakoli A, Dai Q, Chen X, Chakraborty S, et al.
Nucleic Acids Res
. 2020 Oct;
48(21):12348-12364.
PMID: 33119737
XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix-destabilizing/distorting DNA lesions by selectively 'opening' these sites while rapidly diffusing along undamaged DNA. Previous structural studies showed that Rad4, when...
10.
Feher K, Kolbanovskiy A, Durandin A, Shim Y, Min J, Lee Y, et al.
DNA Repair (Amst)
. 2020 Oct;
96:102985.
PMID: 33035795
The Nucleotide Excision Repair (NER) mechanism removes a wide spectrum of structurally different lesions that critically depend on the binding of the DNA damage sensing NER factor XPC-RAD23B (XPC) to...