David A Pan
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Explore the profile of David A Pan including associated specialties, affiliations and a list of published articles.
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10
Citations
1277
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Recent Articles
1.
Freemantle J, Towler M, Hudson E, Macartney T, Zwirek M, Liu D, et al.
J Cell Sci
. 2024 Nov;
137(24).
PMID: 39575556
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular functions in response to changes in energy availability. However, whether AMPK activity is spatially regulated, and the implications for...
2.
Bali U, Barba O, Dawson G, Gattrell W, Horswill J, Pan D, et al.
Bioorg Med Chem Lett
. 2012 Jan;
22(2):824-8.
PMID: 22217874
A series of potent carboxylic acid DGAT1 inhibitors with high permeability were developed from a virtual screening hit. Strategies were employed to reduce Pgp substrate recognition and increase passive permeability,...
3.
Towler M, Fogarty S, Hawley S, Pan D, Martin D, Morrice N, et al.
Biochem J
. 2008 Sep;
416(1):1-14.
PMID: 18774945
LKB1 was discovered as a tumour suppressor mutated in Peutz-Jeghers syndrome, and is a gene involved in cell polarity as well as an upstream protein kinase for members of the...
4.
Viana R, Towler M, Pan D, Carling D, Viollet B, Grahame Hardie D, et al.
J Biol Chem
. 2007 Apr;
282(22):16117-25.
PMID: 17403675
Mammalian AMP-activated protein kinase is a serine/threonine protein kinase that acts as a sensor of cellular energy status. AMP-activated protein kinase is a heterotrimer of three different subunits, i.e. alpha,...
5.
Hawley S, Pan D, Mustard K, Ross L, Bain J, Edelman A, et al.
Cell Metab
. 2005 Aug;
2(1):9-19.
PMID: 16054095
The AMP-activated protein kinase (AMPK) is a critical regulator of energy balance at both the cellular and whole-body levels. Two upstream kinases have been reported to activate AMPK in cell-free...
6.
Dokladda K, Green K, Pan D, Grahame Hardie D
FEBS Lett
. 2004 Dec;
579(1):236-40.
PMID: 15620719
The MAP kinase pathway inhibitor U0126 caused phosphorylation and activation of AMP-activated protein kinase (AMPK) and increased phosphorylation of its downstream target acetyl-CoA carboxylase, in HEK293 cells. This effect only...
7.
Milcamps A, Tumaney A, Paddock T, Pan D, Ohlrogge J, Pollard M
J Biol Chem
. 2004 Dec;
280(7):5370-7.
PMID: 15579902
1,2-Diacyl-3-acetyl-sn-glycerols (ac-TAG) are unusual triacylglycerols that constitute the major storage lipid in the seeds of Euonymus alatus (Burning Bush). These ac-TAGs have long-chain acyl groups esterified at both the sn-1...
8.
Grahame Hardie D, Scott J, Pan D, Hudson E
FEBS Lett
. 2003 Jun;
546(1):113-20.
PMID: 12829246
The AMP-activated protein kinase is a sensor of cellular energy status that is found in all eukaryotic cells. It is activated by rising AMP and falling ATP by a complex...
9.
Hudson E, Pan D, James J, Lucocq J, Hawley S, Green K, et al.
Curr Biol
. 2003 May;
13(10):861-6.
PMID: 12747836
The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that is activated by low cellular energy status and affects a switch away from energy-requiring processes and toward catabolism. While it...
10.
Pan D, Grahame Hardie D
Biochem J
. 2002 Jul;
367(Pt 1):179-86.
PMID: 12093363
We have identified single genes encoding homologues of the alpha, beta and gamma subunits of mammalian AMP-activated protein kinase (AMPK) in the genome of Drosophila melanogaster. Kinase activity could be...