David A OBrochta
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Explore the profile of David A OBrochta including associated specialties, affiliations and a list of published articles.
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36
Citations
1355
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Recent Articles
1.
Combs M, Golnar A, Overcash J, Lloyd A, Hayes K, OBrochta D, et al.
Trends Genet
. 2023 May;
39(8):609-623.
PMID: 37198063
Engineered gene drives create potential for both widespread benefits and irreversible harms to ecosystems. CRISPR-based systems of allelic conversion have rapidly accelerated gene drive research across diverse taxa, putting field...
2.
James S, OBrochta D, Randazzo F, Akbari O
Nat Commun
. 2023 Mar;
14(1):1749.
PMID: 36991021
No abstract available.
3.
Hussien M, Soliman B, Tewfick M, OBrochta D
Pathog Glob Health
. 2022 Aug;
117(3):308-314.
PMID: 35993325
sporozoites associated with the midgut and in the hemolymph of mosquitoes differ from sporozoites in the secretory cavities and ducts of the insects' salivary glands in their transcriptome, proteome, motility,...
4.
Billingsley P, George K, Eappen A, Harrell 2nd R, Alford R, Li T, et al.
Malar J
. 2021 Jun;
20(1):284.
PMID: 34174879
Background: Plasmodium falciparum (Pf) sporozoites (PfSPZ) can be administered as a highly protective vaccine conferring the highest protection seen to date. Sanaria® PfSPZ vaccines are produced using aseptically reared Anopheles...
5.
OBrochta D, Tonui W, Dass B, James S
Appl Biosaf
. 2020 Jul;
25(1):19-27.
PMID: 32655328
Background: Genetic technologies such as gene editing and gene drive create challenges for existing frameworks used to assess risk and make regulatory determinations by governments and institutions. Insect genetic technologies...
6.
OBrochta D, Alford R, Harrell R, Aluvihare C, Eappen A, Li T, et al.
Malar J
. 2019 Jan;
18(1):2.
PMID: 30602380
Background: Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites...
7.
Reid W, Pilitt K, Alford R, Cervantes-Medina A, Yu H, Aluvihare C, et al.
G3 (Bethesda)
. 2018 Aug;
8(10):3119-3130.
PMID: 30135106
The piggyBac transposon was modified to generate gene trap constructs, which were then incorporated into the genome of the Asian malaria vector, and remobilized through genetic crosses using a piggyBac...
8.
Criscione F, OBrochta D, Reid W
Curr Opin Insect Sci
. 2018 Mar;
10:90-97.
PMID: 29588019
The first genetic technologies for insect vectors of disease were introduced 20 years ago. As of today there are 12 classes of genetic technologies used as functional genomic tools for...
9.
Hacker I, Harrell Ii R, Eichner G, Pilitt K, OBrochta D, Handler A, et al.
Sci Rep
. 2017 Mar;
7:43883.
PMID: 28266580
Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a...
10.
Riabinina O, Task D, Marr E, Lin C, Alford R, OBrochta D, et al.
Nat Commun
. 2016 Oct;
7:13010.
PMID: 27694947
Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the...