A Gene Drive is a Gene Drive: the Debate over Lumping or Splitting Definitions

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Mar 29

PMID 36991021

Authors

Stephanie L James

David A OBrochta

Filippo Randazzo

Omar S Akbari

Affiliations

Soon will be listed here.

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Engineered and natural gene drives: mechanistically the same, yet not same in kind.

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Manipulating the Destiny of Wild Populations Using CRISPR.

Raban R, Marshall J, Hay B, Akbari O Annu Rev Genet. 2023; 57:361-390.

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References

Wedell N, Price T, Lindholm A . Gene drive: progress and prospects. Proc Biol Sci. 2019; 286(1917):20192709. PMC: 6939923. DOI: 10.1098/rspb.2019.2709. View

Alphey L, Crisanti A, Randazzo F, Akbari O . Opinion: Standardizing the definition of gene drive. Proc Natl Acad Sci U S A. 2020; 117(49):30864-30867. PMC: 7733814. DOI: 10.1073/pnas.2020417117. View

Gierus L, Birand A, Bunting M, Godahewa G, Piltz S, Oh K . Leveraging a natural murine meiotic drive to suppress invasive populations. Proc Natl Acad Sci U S A. 2022; 119(46):e2213308119. PMC: 9674240. DOI: 10.1073/pnas.2213308119. View

Simon S, Otto M, Engelhard M . Synthetic gene drive: between continuity and novelty: Crucial differences between gene drive and genetically modified organisms require an adapted risk assessment for their use. EMBO Rep. 2018; 19(5). PMC: 5934763. DOI: 10.15252/embr.201845760. View

Price T, Windbichler N, Unckless R, Sutter A, Runge J, Ross P . Resistance to natural and synthetic gene drive systems. J Evol Biol. 2020; 33(10):1345-1360. PMC: 7796552. DOI: 10.1111/jeb.13693. View