David A Lawrence
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Explore the profile of David A Lawrence including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
2487
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Recent Articles
31.
Chang T, Lawrence D, Lu M, Tan J, Harnoss J, Marsters S, et al.
Mol Cell
. 2018 Aug;
71(4):629-636.e5.
PMID: 30118681
The kinases PERK and IRE1 alleviate endoplasmic reticulum (ER) stress by orchestrating the unfolded protein response (UPR). If stress mitigation fails, PERK promotes cell death by activating pro-apoptotic genes, including...
32.
Lam M, Lawrence D, Ashkenazi A, Walter P
Cell Death Differ
. 2018 Jul;
25(8):1530-1531.
PMID: 29991746
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the...
33.
Ghassabian A, Sundaram R, Chahal N, McLain A, Bell E, Lawrence D, et al.
Paediatr Perinat Epidemiol
. 2018 Jul;
32(4):337-345.
PMID: 29972605
Background: Evidence shows cytokine dysregulation in children with developmental disabilities. The association between immune activity during the perinatal period and child development is less clear. Methods: We examined the relationship...
34.
Lee F, Lawrence D
J Toxicol Environ Health B Crit Rev
. 2017 Dec;
21(1):24-46.
PMID: 29252129
A temporal trend can be seen in recent human history where the dominant causes of death have shifted from infectious to chronic diseases in industrialized societies. Human influences in the...
35.
Kasten-Jolly J, Lawrence D
Toxicol Appl Pharmacol
. 2017 Sep;
334:142-157.
PMID: 28911972
The environmental toxicant lead (Pb) has long been known to induce neurological deficits. The 1st century Greek physician Pedanius Dioscorides noted that "lead makes the mind give way". Current studies...
36.
Ghassabian A, Sundaram R, Chahal N, McLain A, Bell E, Lawrence D, et al.
Dev Psychopathol
. 2017 May;
29(4):1499-1511.
PMID: 28462726
Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also...
37.
Chahal N, McLain A, Ghassabian A, Michels K, Bell E, Lawrence D, et al.
Nicotine Tob Res
. 2016 Dec;
19(7):789-796.
PMID: 28011791
Introduction: Prenatal smoking exposure may lead to permanent changes in neonatal inflammation and immune response that have lifelong implications, including increased risks for atopy and respiratory disorders. Methods: The effect...
38.
Lawrence D, Trotta B, Shen F, Druzgal J, Fox M
Skeletal Radiol
. 2016 Jul;
45(9):1285-9.
PMID: 27380319
Objective: Determine the MRI characteristics of large post-traumatic cervical spine extra-arachnoid collections managed conservatively in clinically stable patients and whether evidence of clinical or imaging deterioration materialized. Materials And Methods:...
39.
Kremer J, Lawrence D, Hamilton R, McInnes I
RMD Open
. 2016 Jun;
2(1):e000287.
PMID: 27335660
Objective: To describe changes in immune parameters observed during long-term methotrexate (MTX) therapy in patients with active rheumatoid arthritis (RA) and explore correlations with simultaneously measured MTX pharmacokinetic (PKC) parameters....
40.
Stensby J, Lawrence D, Patrie J, Gaskin C
Skeletal Radiol
. 2016 Apr;
45(7):949-54.
PMID: 27037810
Objective: To determine trends in incidentally detected age- and gender-associated chondrocalcinosis on pelvic CT. Materials And Methods: Twenty patients of each gender at the center of each decade of life...