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David A Lawrence

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Articles 126
Citations 2487
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Recent Articles
11.
Jones L, Ghassabian A, Lawrence D, Sundaram R, Yeung E, Kannan K, et al.
Environ Pollut . 2022 Jul; 308:119656. PMID: 35787426
Infant exposure to per/polyfluoroalkyl compounds is associated with immune disruption. We examined associations between neonatal concentrations of perflurooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) and immunoglobulin (Ig) isotype profiles in...
12.
Yao Y, Uddin M, Manley K, Lawrence D
J Neuroimmunol . 2022 May; 368:577893. PMID: 35617718
Mitochondria-mediated metabolic impairment and dysfunction are highly related with autism. Herein, the mitochondria-mediated metabolism of BTBR TItpr3/J (BTBR) mice with autistic-like behaviors was investigated. A new BTBR-mt strain generated by...
13.
Kasten-Jolly J, Lawrence D
J Toxicol Environ Health A . 2022 May; 85(17):715-737. PMID: 35611390
Environmental contaminants perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) are present in human serum at the highest concentration among all per- and polyfluoroalkyl substances (PFAS). Serum concentrations as high as 500 ng...
14.
Monaco-Brown M, Lawrence D
Front Pediatr . 2022 May; 10:859885. PMID: 35573953
Obesity rates in women of childbearing age is now at 29%, according to recent CDC reports. It is known that obesity is associated with oxidative stress and inflammation, including disruptions...
15.
Guttman O, Le Thomas A, Marsters S, Lawrence D, Gutgesell L, Zuazo-Gaztelu I, et al.
J Cell Biol . 2022 Apr; 221(6). PMID: 35446348
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major...
16.
Kasten-Jolly J, Lawrence D
Immunol Res . 2022 Jan; 70(1):114-128. PMID: 35023048
Blood was collected from the New York State Department of Health (NYSDOH) employees to assess variances in leukocyte numbers in January, May, and September throughout a year and over many...
17.
Yao Y, Uddin M, Manley K, Lawrence D
Cell Biochem Funct . 2022 Jan; 40(2):150-162. PMID: 34978084
Gene and protein expression of BTBR T Itpr3 /J (BTBR) mice with autistic-like behaviours were compared with the C57BL/6J strain, which is considered to have normal immunity and behaviour. Notch...
18.
Le Thomas A, Ferri E, Marsters S, Harnoss J, Lawrence D, Zuazo-Gaztelu I, et al.
Nat Commun . 2021 Dec; 12(1):7310. PMID: 34911951
Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates...
19.
Uddin M, Yao Y, Mondal T, Matala R, Manley K, Lin Q, et al.
Brain Behav Immun Health . 2021 Sep; 4:100069. PMID: 34589851
Female and male mice of the BTBR /J (BTBR) strain have behaviors that resemble autism spectrum disorder. In comparison to C57BL/6 (B6) mice, BTBR mice have elevated humoral immunity, in...
20.
Bell E, De Guise S, McCutcheon J, Lei Y, Levin M, Li B, et al.
Sci Total Environ . 2021 Mar; 780:146399. PMID: 33770593
Per- and polyfluoroalkyl substances (PFAS) make up a large group of persistent anthropogenic chemicals which are difficult to degrade and/or destroy. PFAS are an emerging class of contaminants, but little...