David A Lane
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Explore the profile of David A Lane including associated specialties, affiliations and a list of published articles.
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61
Citations
1339
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Recent Articles
1.
Teraz-Orosz A, Gierula M, Petri A, Jones D, Keniyopoullos R, Folgado P, et al.
Blood Adv
. 2021 Nov;
6(2):704-715.
PMID: 34731882
Protein S is a cofactor in the tissue factor pathway inhibitor (TFPI) anticoagulant pathway. It enhances TFPIα-mediated inhibition of factor (F)Xa activity and generation. The enhancement is dependent on a...
2.
Ahnstrom J, Gierula M, Temenu J, Laffan M, Lane D
J Thromb Haemost
. 2019 Aug;
18(1):136-150.
PMID: 31466141
Background: Activated coagulation factor X (FXa) is the serine protease component of prothrombinase, the physiological activator of prothrombin. Factor X Nottingham (A404T) and Taunton (R405G) are two naturally occurring mutations,...
3.
Gierula M, Salles-Crawley I, Santamaria S, Teraz-Orosz A, Crawley J, Lane D, et al.
J Thromb Haemost
. 2019 Aug;
17(12):2056-2068.
PMID: 31364267
Background: Activated protein C (APC)-mediated inactivation of factor (F)Va is greatly enhanced by protein S. For inactivation to occur, a trimolecular complex among FVa, APC, and protein S must form...
4.
Santamaria S, Yamamoto K, Teraz-Orosz A, Koch C, Apte S, de Groot R, et al.
Sci Rep
. 2019 Jul;
9(1):10914.
PMID: 31358852
ADAMTS (A Disintegrin-like and Metalloproteinase domain with Thrombospondin type 1 Motif)-1, -4 and -5 share the abilities to cleave large aggregating proteoglycans including versican and aggrecan. These activities are highly...
5.
Crawley J, Zalli A, Monkman J, Petri A, Lane D, Ahnstrom J, et al.
J Thromb Haemost
. 2019 Jul;
17(11):1935-1949.
PMID: 31351019
Background: Bone morphogenetic and activin membrane-bound inhibitor (BAMBI) is a transmembrane protein related to the type I transforming growth factor- β (TGF-β) receptor family that is present on both platelets...
6.
Newnham M, South K, Bleda M, Auger W, Barbera J, Bogaard H, et al.
Eur Respir J
. 2019 Jan;
53(3).
PMID: 30655285
Chronic thromboembolic pulmonary hypertension (CTEPH) is an important consequence of pulmonary embolism that is associated with abnormalities in haemostasis. We investigated the ADAMTS13-von Willebrand factor (VWF) axis in CTEPH, including...
7.
Thwaites R, Gunawardana N, Broich V, Mann E, Ahnstrom J, Campbell G, et al.
J Allergy Clin Immunol
. 2018 Feb;
141(5):1892-1895.e6.
PMID: 29427640
No abstract available.
8.
South K, Freitas M, Lane D
J Biol Chem
. 2018 Jan;
293(4):1149-1150.
PMID: 29374083
No abstract available.
9.
Lynch C, Cawte A, Millar C, Rueda D, Lane D
PLoS One
. 2017 Nov;
12(11):e0188405.
PMID: 29186156
Rheological forces in the blood trigger the unfolding of von Willebrand factor (VWF) and its A2 domain, exposing the scissile bond for proteolysis by ADAMTS13. Under quiescent conditions, the scissile...
10.
Santamaria S, Reglinska-Matveyev N, Gierula M, Camire R, Crawley J, Lane D, et al.
J Biol Chem
. 2017 Apr;
292(22):9335-9344.
PMID: 28420729
Tissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa. Protein S is...