Darshan V Trivedi
Overview
Explore the profile of Darshan V Trivedi including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
752
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Recent Articles
1.
Nag S, Trivedi D
Elife
. 2021 Feb;
10.
PMID: 33565963
Since the discovery of muscle in the 19th century, myosins as molecular motors have been extensively studied. However, in the last decade, a new functional super-relaxed (SRX) state of myosin...
2.
Gyimesi M, Horvath A, Turos D, Suthar S, Penzes M, Kurdi C, et al.
Cell
. 2020 Oct;
183(2):335-346.e13.
PMID: 33035452
Muscle spasticity after nervous system injuries and painful low back spasm affect more than 10% of global population. Current medications are of limited efficacy and cause neurological and cardiovascular side...
3.
Sarkar S, Trivedi D, Morck M, Adhikari A, Pasha S, Ruppel K, et al.
Sci Adv
. 2020 Apr;
6(14):eaax0069.
PMID: 32284968
Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the...
4.
Trivedi D, Nag S, Spudich A, Ruppel K, Spudich J
Annu Rev Biochem
. 2020 Mar;
89:667-693.
PMID: 32169021
Myosins are among the most fascinating enzymes in biology. As extremely allosteric chemomechanical molecular machines, myosins are involved in myriad pivotal cellular functions and are frequently sites of mutations leading...
5.
Adhikari A, Trivedi D, Sarkar S, Song D, Kooiker K, Bernstein D, et al.
Nat Commun
. 2019 Jun;
10(1):2685.
PMID: 31213605
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking...
6.
Wilkinson A, Diep J, Dai S, Liu S, Ooi Y, Song D, et al.
Nature
. 2019 Jan;
565(7739):372-376.
PMID: 30626964
For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur. Despite the pervasiveness of His73 methylation, which we find is conserved in...
7.
Gunther L, Rohde J, Tang W, Walton S, Unrath W, Trivedi D, et al.
J Biol Chem
. 2018 Dec;
294(5):1554-1567.
PMID: 30518549
Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how...
8.
Anderson R, Trivedi D, Sarkar S, Henze M, Ma W, Gong H, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(35):E8143-E8152.
PMID: 30104387
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of...
9.
Trivedi D, Adhikari A, Sarkar S, Ruppel K, Spudich J
Biophys Rev
. 2017 Jul;
10(1):27-48.
PMID: 28717924
The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood throughout the body. At...
10.
Nag S, Trivedi D, Sarkar S, Adhikari A, Sunitha M, Sutton S, et al.
Nat Struct Mol Biol
. 2017 May;
24(6):525-533.
PMID: 28481356
Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin measured so far do not explain the clinical...