Saswata S Sarkar
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Explore the profile of Saswata S Sarkar including associated specialties, affiliations and a list of published articles.
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8
Citations
643
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Recent Articles
1.
Sarkar S, Trivedi D, Morck M, Adhikari A, Pasha S, Ruppel K, et al.
Sci Adv
. 2020 Apr;
6(14):eaax0069.
PMID: 32284968
Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the...
2.
Adhikari A, Trivedi D, Sarkar S, Song D, Kooiker K, Bernstein D, et al.
Nat Commun
. 2019 Jun;
10(1):2685.
PMID: 31213605
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found in human β-cardiac myosin. Previous studies looking...
3.
Anderson R, Trivedi D, Sarkar S, Henze M, Ma W, Gong H, et al.
Proc Natl Acad Sci U S A
. 2018 Aug;
115(35):E8143-E8152.
PMID: 30104387
Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However, measurements of the intrinsic force, velocity, and ATPase activity of...
4.
Trivedi D, Adhikari A, Sarkar S, Ruppel K, Spudich J
Biophys Rev
. 2017 Jul;
10(1):27-48.
PMID: 28717924
The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood throughout the body. At...
5.
Nag S, Trivedi D, Sarkar S, Adhikari A, Sunitha M, Sutton S, et al.
Nat Struct Mol Biol
. 2017 May;
24(6):525-533.
PMID: 28481356
Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin measured so far do not explain the clinical...
6.
Kawana M, Sarkar S, Sutton S, Ruppel K, Spudich J
Sci Adv
. 2017 Mar;
3(2):e1601959.
PMID: 28246639
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward...
7.
Adhikari A, Kooiker K, Sarkar S, Liu C, Bernstein D, Spudich J, et al.
Cell Rep
. 2016 Dec;
17(11):2857-2864.
PMID: 27974200
Hypertrophic cardiomyopathy (HCM) is a heritable cardiovascular disorder that affects 1 in 500 people. A significant percentage of HCM is attributed to mutations in β-cardiac myosin, the motor protein that...
8.
Spudich J, Aksel T, Bartholomew S, Nag S, Kawana M, Yu E, et al.
J Exp Biol
. 2016 Jan;
219(Pt 2):161-7.
PMID: 26792326
Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that...