Darryl Aucoin
Overview
Explore the profile of Darryl Aucoin including associated specialties, affiliations and a list of published articles.
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9
Citations
626
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Recent Articles
1.
Aucoin D, Xia Y, Theint T, Nadaud P, Surewicz K, Surewicz W, et al.
J Struct Biol
. 2018 Apr;
206(1):36-42.
PMID: 29679649
The C-terminally truncated Y145Stop variant of prion protein (PrP23-144), which is associated with heritable PrP cerebral amyloid angiopathy in humans and also capable of triggering a transmissible prion disease in...
2.
Theint T, Nadaud P, Aucoin D, Helmus J, Pondaven S, Surewicz K, et al.
Nat Commun
. 2017 Oct;
8(1):753.
PMID: 28963458
One of the most puzzling aspects of the prion diseases is the intricate relationship between prion strains and interspecies transmissibility barriers. Previously we have shown that certain fundamental aspects of...
3.
Fu Z, Aucoin D, Davis J, Van Nostrand W, Smith S
Biochemistry
. 2015 Jun;
54(27):4197-207.
PMID: 26069943
Soluble oligomers and protofibrils of the Aβ42 peptide are neurotoxic intermediates in the conversion of monomeric Aβ42 into the amyloid fibrils associated with Alzheimer's disease. Nuclear magnetic resonance and Fourier...
4.
Fu Z, Aucoin D, Ahmed M, Ziliox M, Van Nostrand W, Smith S
Biochemistry
. 2014 Nov;
53(50):7893-903.
PMID: 25422864
Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be more toxic to...
5.
Kotarba A, Aucoin D, Hoos M, Smith S, Van Nostrand W
Biochemistry
. 2013 Mar;
52(15):2565-73.
PMID: 23510371
The assembly and deposition of amyloid β-protein (Aβ) in brain is a key pathological feature of Alzheimer's disease and related disorders. Factors have been identified that can either promote or...
6.
Liu G, Prabhakar A, Aucoin D, Simon M, Sparks S, Robbins K, et al.
J Am Chem Soc
. 2010 Dec;
132(51):18223-32.
PMID: 21138275
The pathologic self-assembly of proteins is associated with typically late-onset disorders such as Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Important mechanistic details of the self-assembly are unknown, but...
7.
Liao M, Hoos M, Aucoin D, Ahmed M, Davis J, Smith S, et al.
J Biol Chem
. 2010 Sep;
285(46):35590-8.
PMID: 20807757
Accumulation of amyloid β-protein (Aβ) into brain parenchymal plaques and the cerebral vasculature is a pathological feature of Alzheimer disease and related disorders. Aβ peptides readily form β-sheet-containing oligomers and...
8.
Ahmed M, Davis J, Aucoin D, Sato T, Ahuja S, Aimoto S, et al.
Nat Struct Mol Biol
. 2010 Apr;
17(5):561-7.
PMID: 20383142
The amyloid-beta(1-42) (Abeta42) peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that low-temperature and low-salt...
9.
Aucoin D, Camenares D, Zhao X, Jung J, Sato T, Smith S
J Magn Reson
. 2009 Jan;
197(1):77-86.
PMID: 19121592
The combination of magic angle spinning (MAS) with the high-resolution (1)H NOESY NMR experiment is an established method for measuring through-space (1)H...(1)H dipolar couplings in biological membranes. The segmental motion...