Darrian Bugg
Overview
Explore the profile of Darrian Bugg including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
372
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0
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Recent Articles
1.
Ngwenyama N, Kaur K, Bugg D, Theall B, Aronovitz M, Berland R, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(12):1230.
PMID: 39196170
No abstract available.
2.
Bugg D, Davis J
Cell Stem Cell
. 2024 May;
31(5):589-590.
PMID: 38701754
Poorly regenerative organs deposit scar tissue to mend damage. Aggarwal et al. establish that transient Sox9 activity is necessary for early proximal tubule epithelial regeneration, while Trogisch et al. and...
3.
Bailey L, Bugg D, Reichardt I, Ortac C, Nagle A, Gunaje J, et al.
Circulation
. 2024 Mar;
149(23):1812-1829.
PMID: 38426339
Background: Discovering determinants of cardiomyocyte maturity is critical for deeply understanding the maintenance of differentiated states and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic strategy....
4.
Nelson A, Bugg D, Davis J, Saucerman J
iScience
. 2023 Apr;
26(4):106502.
PMID: 37091233
RNA-binding protein muscleblind-like1 (MBNL1) was recently identified as a central regulator of cardiac wound healing and myofibroblast activation. To identify putative MBNL1 targets, we integrated multiple genome-wide screens with a...
5.
Bailey L, Bugg D, Reichardt I, Ortac C, Gunaje J, Johnson R, et al.
bioRxiv
. 2023 Mar;
PMID: 36993225
Discovering determinants of cardiomyocyte maturity and the maintenance of differentiated states is critical to both understanding development and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic...
6.
Bretherton R, Haack A, Kopyeva I, Rahman F, Kern J, Bugg D, et al.
Adv Mater
. 2023 Feb;
35(19):e2209904.
PMID: 36808641
Stimuli-responsive biomaterials show great promise for modeling disease dynamics ex vivo with spatiotemporal control over the cellular microenvironment. However, harvesting cells from such materials for downstream analysis without perturbing their...
7.
Bretherton R, Reichardt I, Zabrecky K, Goldstein A, Bailey L, Bugg D, et al.
bioRxiv
. 2023 Feb;
PMID: 36747691
Inherited mutations in contractile and structural genes, which decrease cardiomyocyte tension generation, are principal drivers of dilated cardiomyopathy (DCM)- the leading cause of heart failure . Progress towards developing precision...
8.
Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, et al.
J Clin Invest
. 2022 Dec;
133(4).
PMID: 36480284
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the...
9.
Ngwenyama N, Kaur K, Bugg D, Theall B, Aronovitz M, Berland R, et al.
Nat Cardiovasc Res
. 2022 Sep;
1(8):761-774.
PMID: 36092510
Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models and patients with HF revealed a prominent role for CD4+ T cell immune responses in...
10.
Bugg D, Bailey L, Bretherton R, Beach K, Reichardt I, Robeson K, et al.
Cell Stem Cell
. 2022 Feb;
29(3):419-433.e10.
PMID: 35176223
Dynamic fibroblast to myofibroblast state transitions underlie the heart's fibrotic response. Because transcriptome maturation by muscleblind-like 1 (MBNL1) promotes differentiated cell states, this study investigated whether tactical control of MBNL1...