Darren Qiancheng Tan
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Explore the profile of Darren Qiancheng Tan including associated specialties, affiliations and a list of published articles.
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10
Citations
155
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Recent Articles
1.
Niibori-Nambu A, Wang C, Chin D, Chooi J, Hosoi H, Sonoki T, et al.
Gene
. 2024 Jul;
928:148761.
PMID: 39002785
Leukemia stem cells (LSCs) are widely believed to reside in well-characterized bone marrow (BM) niches; however, the capacity of the BM niches to accommodate LSCs is insufficient, and a significant...
2.
Yang C, Yokomori R, Chua L, Tan S, Tan D, Miharada K, et al.
J Exp Med
. 2022 Sep;
219(12).
PMID: 36112140
Intercellular mitochondria transfer is a biological phenomenon implicated in diverse biological processes. However, the physiological role of this phenomenon remains understudied between erythroblasts and their erythroblastic island (EBI) macrophage niche....
3.
Rethnam M, Tan D, Tan S, Li J, Yokomori R, Li Y, et al.
Blood Adv
. 2022 Apr;
6(18):5330-5344.
PMID: 35482445
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy with poor clinical outcomes. Dysregulated MYC expression, which is associated with protein arginine methyltransferase 5 (PRMT5) dependency,...
4.
Nakamura-Ishizu A, Chin D, Matsumura T, Tan D, Mochizuki-Kashio M, Jianwen D, et al.
Blood
. 2021 Mar;
137(19):2609-2620.
PMID: 33657206
Hematopoietic stem cells (HSC) rarely divide, rest in quiescence, and proliferate only upon stress hematopoiesis. The cytokine thrombopoietin (Thpo) has been perplexingly described to induce quiescence and promote self-renewal divisions...
5.
Rethnam M, Tan D, Suda T
Biochem Biophys Res Commun
. 2020 Nov;
534:843-848.
PMID: 33183761
Multiple myeloma (MM) is an intractable hematological malignancy characterized by abnormal plasma cells in the bone marrow (BM) and increased osteolytic lesions. Within the BM niche, mesenchymal stem cells (MSCs)...
6.
Matsumura T, Nakamura-Ishizu A, Muddineni S, Tan D, Wang C, Tokunaga K, et al.
Blood
. 2020 Jun;
136(17):1919-1932.
PMID: 32573733
RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negative suppression of RUNX1 function is found in myelodysplastic syndrome and acute myeloid leukemia (AML)....
7.
Takihara Y, Nakamura-Ishizu A, Tan D, Fukuda M, Matsumura T, Endoh M, et al.
Blood Adv
. 2019 Aug;
3(15):2323-2327.
PMID: 31387881
No abstract available.
8.
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells
Tan D, Li Y, Yang C, Li J, Tan S, Chin D, et al.
Cell Rep
. 2019 Feb;
26(9):2316-2328.e6.
PMID: 30811983
Protein arginine methyltransferase 5 (PRMT5) is essential for hematopoiesis, while PRMT5 inhibition remains a promising therapeutic strategy against various cancers. Here, we demonstrate that hematopoietic stem cell (HSC) quiescence and...
9.
Yang C, Hashimoto M, Xuan Lin Q, Tan D, Suda T
Exp Hematol
. 2019 Jan;
72:47-59.e1.
PMID: 30658118
Erythropoiesis is a highly coordinated stepwise process involving the progressive clearance of mitochondria via mitophagy. Based on the expression of several macroautophagy and mitophagy specific genes, we identified a sequential...
10.
Tan D, Zhang L, Ohba K, Ye M, Ichiyama K, Yamamoto N
Eur J Immunol
. 2016 Jan;
46(4):919-28.
PMID: 26763072
Tumor-associated macrophages (TAMs) are known to regulate tumor response to many anti-cancer therapies, including oncolytic virotherapy. Oncolytic virotherapy employing oncolytic paramyxoviruses, such as attenuated measles (MeV) and mumps (MuV) viruses,...