Michihiro Hashimoto
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Explore the profile of Michihiro Hashimoto including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
556
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Recent Articles
1.
Hashimoto M, Goto A, Qiao S, Yamashita H
Biochem Biophys Res Commun
. 2025 Feb;
753:151454.
PMID: 39978253
Cellular repressor of E1A-stimulated genes 1 (CREG1) is a multifunctional secreted glycoprotein that regulates p16-dependent cellular senescence and cell differentiation and accelerates brown adipogenesis. We recently demonstrated that the CREG1...
2.
Li J, Bai J, Pham V, Hashimoto M, Sezaki M, Shi Q, et al.
J Clin Invest
. 2025 Jan;
135(5).
PMID: 39786963
Hematopoietic stem cells (HSCs) rely on self-renewal to sustain stem cell potential and undergo differentiation to generate mature blood cells. Mitochondrial fatty acid β-oxidation (FAO) is essential for HSC maintenance....
3.
Kawaguchi T, Hashimoto M, Nakagawa R, Minami R, Ikawa M, Nakayama J, et al.
Sci Rep
. 2024 Sep;
14(1):21305.
PMID: 39266663
During the development of multicellular organisms and cell differentiation, the chromatin structure in the cell nucleus undergoes extensive changes, and the nucleosome structure is formed by a combination of various...
4.
Ma W, Ahmad S, Hashimoto M, Khalilnezhad A, Kataoka M, Arima Y, et al.
EMBO J
. 2024 Jan;
43(3):339-361.
PMID: 38238476
Hematopoietic stem cell (HSC) divisional fate and function are determined by cellular metabolism, yet the contribution of specific cellular organelles and metabolic pathways to blood maintenance and stress-induced responses in...
5.
Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, et al.
Commun Biol
. 2022 Aug;
5(1):776.
PMID: 35918480
Hematopoietic stem cells (HSCs) are produced from the blood vessel walls and circulate in the blood during the perinatal period. However, the migration dynamics of how HSCs enter the bone...
6.
Umemoto T, Johansson A, Ahmad S, Hashimoto M, Kubota S, Kikuchi K, et al.
EMBO J
. 2022 Mar;
41(8):e109463.
PMID: 35229328
In order to support bone marrow regeneration after myeloablation, hematopoietic stem cells (HSCs) actively divide to provide both stem and progenitor cells. However, the mechanisms regulating HSC function and cell...
7.
Endo Y, Hashimoto M, Kusudo T, Okada T, Takeuchi T, Goto A, et al.
Genes Cells
. 2022 Jan;
27(3):202-213.
PMID: 35007381
Thermogenic brown and beige adipocytes express uncoupling protein 1 (UCP1) and stimulate energy metabolism, protecting against obesity and metabolic diseases such as type 2 diabetes and hyperlipidemia. Cellular repressor of...
8.
Kawaguchi K, Hashimoto M, Mikawa R, Asai A, Sato T, Sugimoto M
STAR Protoc
. 2021 Dec;
2(4):100993.
PMID: 34927099
Cellular senescence underlies tissue aging and aging-associated pathologies, as well as lung pathology. We and others have shown that elimination of senescent cells alleviates pulmonary diseases such as fibrosis and...
9.
Kusudo T, Okada T, Hashimoto M, Takeuchi T, Endo Y, Niwa A, et al.
J Biochem
. 2021 Oct;
171(1):63-73.
PMID: 34647124
Brown and beige adipocytes, which express thermogenic uncoupling protein-1 (UCP1), stimulate glucose and lipid metabolism, improving obesity and metabolic diseases such as type 2 diabetes and hyperlipidemia. Overexpression of cellular...
10.
Hashimoto M, Umemoto T, Nakamura-Ishizu A, Matsumura T, Yokomizo T, Sezaki M, et al.
Blood Adv
. 2021 Mar;
5(6):1594-1604.
PMID: 33710340
Hematopoietic stem cells (HSCs) undergo self-renewal or differentiation to sustain lifelong hematopoiesis. HSCs are preserved in quiescence with low mitochondrial activity. Recent studies indicate that autophagy contributes to HSC quiescence...