Darren A Cusanovich
Overview
Explore the profile of Darren A Cusanovich including associated specialties, affiliations and a list of published articles.
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32
Citations
3676
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Recent Articles
1.
Cabel C, Guzman B, Alizadeh E, Li S, Holberg C, Wichaidit C, et al.
bioRxiv
. 2024 Oct;
PMID: 39416139
The sudden rise of the SARS-CoV-2 virus and the delay in the development of effective therapeutics to mitigate it made evident a need for ways to screen for compounds that...
2.
Adelus M, Ding J, Tran B, Conklin A, Golebiewski A, Stolze L, et al.
Elife
. 2024 Apr;
12.
PMID: 38578680
Heterogeneity in endothelial cell (EC) sub-phenotypes is becoming increasingly appreciated in atherosclerosis progression. Still, studies quantifying EC heterogeneity across whole transcriptomes and epigenomes in both in vitro and in vivo...
3.
Zhang H, Mulqueen R, Iannuzo N, Farrera D, Polverino F, Galligan J, et al.
Genome Biol
. 2024 Mar;
25(1):78.
PMID: 38519979
We develop a large-scale single-cell ATAC-seq method by combining Tn5-based pre-indexing with 10× Genomics barcoding, enabling the indexing of up to 200,000 nuclei across multiple samples in a single reaction....
4.
Trujillo M, Jennings E, Hoffman E, Zhang H, Phoebe A, Mastin G, et al.
Mol Metab
. 2024 Feb;
81:101888.
PMID: 38307385
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in...
5.
Iannuzo N, Welfley H, Li N, Johnson M, Rojas-Quintero J, Polverino F, et al.
Front Immunol
. 2023 Dec;
14:1277582.
PMID: 38053993
Rationale: CC16 (Club Cell Secretory Protein) is a protein produced by club cells and other non-ciliated epithelial cells within the lungs. CC16 has been shown to protect against the development...
6.
Trujillo M, Jennings E, Hoffman E, Zhang H, Phoebe A, Mastin G, et al.
bioRxiv
. 2023 Oct;
PMID: 37873172
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in...
7.
Welfley H, Kylat R, Zaghloul N, Halonen M, Martinez F, Ahmed M, et al.
Am J Respir Cell Mol Biol
. 2023 Aug;
69(6):689-697.
PMID: 37643399
Single-cell genomic technologies hold great potential to advance our understanding of lung development and disease. A major limitation lies in accessing intact cells from primary lung tissues for profiling human...
8.
Kang H, Fitch J, Varghese R, Thorne C, Cusanovich D
bioRxiv
. 2023 May;
PMID: 37214915
Gene regulatory networks, which control gene expression patterns in development and in response to stimuli, use regulatory logic modules to coordinate inputs and outputs. One example of a regulatory logic...
9.
Adelus M, Ding J, Tran B, Conklin A, Golebiewski A, Stolze L, et al.
bioRxiv
. 2023 Apr;
PMID: 37066416
Objective: Endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs) are major cell types in atherosclerosis progression, and heterogeneity in EC sub-phenotypes are becoming increasingly appreciated. Still, studies quantifying...
10.
Zhang H, Rice M, Alvin J, Farrera-Gaffney D, Galligan J, Johnson M, et al.
BMC Genomics
. 2022 Mar;
23(1):214.
PMID: 35296236
Background: The "Assay for Transposase Accessible Chromatin sequencing" (ATAC-seq) is an efficient and easy to implement protocol to measure chromatin accessibility that has been widely used in multiple applications studying...