Daqian Xu
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Explore the profile of Daqian Xu including associated specialties, affiliations and a list of published articles.
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51
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1619
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Recent Articles
21.
Xu D, Shao F, Bian X, Meng Y, Liang T, Lu Z
Cell Metab
. 2021 Jan;
33(1):33-50.
PMID: 33406403
Key pathological, including oncogenic, signaling pathways regulate the canonical functions of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling pathways also confer a large number of metabolic...
22.
Shao F, Bian X, Jiang H, Zhao G, Zhu L, Xu D, et al.
Eur J Cancer
. 2020 Dec;
142:123-131.
PMID: 33278777
Background: Metabolic enzymes have non-canonical functions and play vital roles in the regulation of various cellular activities. Phosphoenolpyruvate carboxykinase 1 (PCK1), a gluconeogenic enzyme, was recently identified as an AKT-dependent...
23.
Xu D, Sun Q, Lin J, Sun W
Chem Commun (Camb)
. 2020 Sep;
56(86):13101-13104.
PMID: 32974625
A novel manganese catalyst bearing an l-proline-derived N4 ligand has been developed for enabling acid-free asymmetric epoxidation of olefins with tert-butyl hydroperoxide as the oxidant. A variety of olefins that...
24.
Du L, Lee J, Jiang H, Wang C, Wang S, Zheng Z, et al.
J Exp Med
. 2020 Aug;
217(11).
PMID: 32860047
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of the β-catenin/TCF/LEF complex to the CD274...
25.
Jiang H, Zhu L, Xu D, Lu Z
Cancer Commun (Lond)
. 2020 Aug;
40(9):389-394.
PMID: 32809272
Highly active lipogenesis is essential for rapid tumor growth. Sterol regulatory element-binding protein (SREBP) is a key transcriptional factor for lipogenesis and activated by reduced sterol and oxysterol levels. However,...
26.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, et al.
Nature
. 2020 Apr;
580(7804):530-535.
PMID: 32322062
Cancer cells increase lipogenesis for their proliferation and the activation of sterol regulatory element-binding proteins (SREBPs) has a central role in this process. SREBPs are inhibited by a complex composed...
27.
Li X, Qian X, Wang B, Xia Y, Zheng Y, Du L, et al.
Nat Cell Biol
. 2020 Feb;
22(3):282-288.
PMID: 32066906
Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR interference and programmable base editing have transformed the manipulation of eukaryotic genomes for potential therapeutic applications. Here, we exploited CRISPR interference and...
28.
Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, et al.
Mol Cell
. 2019 Oct;
76(6):885-895.e7.
PMID: 31629659
Hypoxia, which occurs during tumor growth, triggers complex adaptive responses in which peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) plays a critical role in mitochondrial biogenesis and oxidative metabolism. However,...
29.
Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, et al.
Mol Cell
. 2019 Sep;
76(3):516-527.e7.
PMID: 31492635
The PTEN tumor suppressor is frequently mutated or deleted in cancer and regulates glucose metabolism through the PI3K-AKT pathway. However, whether PTEN directly regulates glycolysis in tumor cells is unclear....
30.
Xu D, Li X, Shao F, Lv G, Lv H, Lee J, et al.
Sci Adv
. 2019 Apr;
5(4):eaav4570.
PMID: 31032410
Cancer cells often encounter oxidative stress. However, it is unclear whether normal and cancer cells differentially respond to oxidative stress. Here, we demonstrated that under oxidative stress, hepatocellular carcinoma (HCC)...