Daphne H E W Huberts
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Explore the profile of Daphne H E W Huberts including associated specialties, affiliations and a list of published articles.
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12
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500
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Recent Articles
1.
Wit N, Gogola E, West J, Vornbaumen T, Seear R, Bailey P, et al.
Sci Adv
. 2023 May;
9(20):eadg2235.
PMID: 37196082
Cells produce considerable genotoxic formaldehyde from an unknown source. We carry out a genome-wide CRISPR-Cas9 genetic screen in metabolically engineered HAP1 cells that are auxotrophic for formaldehyde to find this...
2.
Litsios A, Huberts D, Terpstra H, Guerra P, Schmidt A, Buczak K, et al.
Nat Cell Biol
. 2019 Nov;
21(11):1382-1392.
PMID: 31685990
In the unicellular eukaryote Saccharomyces cerevisiae, Cln3-cyclin-dependent kinase activity enables Start, the irreversible commitment to the cell division cycle. However, the concentration of Cln3 has been paradoxically considered to remain...
3.
Huberts D, Gonzalez J, Lee S, Litsios A, Hubmann G, Wit E, et al.
Proc Natl Acad Sci U S A
. 2014 Jul;
111(32):11727-31.
PMID: 25071164
Calorie restriction (CR) is often described as the most robust manner to extend lifespan in a large variety of organisms. Hence, considerable research effort is directed toward understanding the mechanisms...
4.
van Diepeningen A, Engelmoer D, Sellem C, Huberts D, Slakhorst S, Sainsard-Chanet A, et al.
Philos Trans R Soc Lond B Biol Sci
. 2014 May;
369(1646):20130447.
PMID: 24864315
Autophagy is a well-conserved catabolic process, involving the degradation of a cell's own components through the lysosomal/vacuolar machinery. Autophagy is typically induced by nutrient starvation and has a role in...
5.
Huberts D, Janssens G, Lee S, Vizcarra I, Heinemann M
J Vis Exp
. 2013 Sep;
(78):e50143.
PMID: 23995364
We demonstrate the use of a simple microfluidic setup, in which single budding yeast cells can be tracked throughout their entire lifespan. The microfluidic chip exploits the size difference between...
6.
Huberts D, Lee S, Gonzales J, Janssens G, Vizcarra I, Heinemann M
Nat Protoc
. 2013 May;
8(6):1019-27.
PMID: 23640166
This protocol describes the production and operation of a microfluidic dissection platform for long-term, high-resolution imaging of budding yeast cells. At the core of this platform is an array of...
7.
Lee S, Vizcarra I, Huberts D, Lee L, Heinemann M
Proc Natl Acad Sci U S A
. 2012 Mar;
109(13):4916-20.
PMID: 22421136
Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g.,...
8.
Huberts D, Niebel B, Heinemann M
FEMS Yeast Res
. 2011 Dec;
12(2):118-28.
PMID: 22129078
The yeast Saccharomyces cerevisiae can show different metabolic phenotypes (e.g. fermentation and respiration). Based on data from the literature, we argue that the substrate uptake rate is the core variable...
9.
The moonlighting function of pyruvate carboxylase resides in the non-catalytic end of the TIM barrel
Huberts D, Venselaar H, Vriend G, Veenhuis M, van der Klei I
Biochim Biophys Acta
. 2010 Apr;
1803(9):1038-42.
PMID: 20359504
Pyruvate carboxylase is a highly conserved enzyme that functions in replenishing the tricarboxylic acid cycle with oxaloacetate. In the yeast Hansenulapolymorpha, the pyruvate carboxylase protein is also required for import...
10.
Huberts D, van der Klei I
Biochim Biophys Acta
. 2010 Feb;
1803(4):520-5.
PMID: 20144902
Proteins are macromolecules, which perform a large variety of functions. Most of them have only a single function, but an increasing number of proteins are being identified as multifunctional. Moonlighting...