Daoming Qin
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Explore the profile of Daoming Qin including associated specialties, affiliations and a list of published articles.
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12
Citations
258
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Recent Articles
1.
Zhou F, Bocetti J, Hou M, Qin D, Hinnebusch A, Lorsch J
Elife
. 2024 Apr;
13.
PMID: 38573742
We have developed a deep sequencing-based approach, Rec-Seq, that allows simultaneous monitoring of ribosomal 48S preinitiation complex (PIC) formation on every mRNA in the translatome in an in vitro reconstituted...
2.
Zhou F, Bocetti J, Hou M, Qin D, Hinnebusch A, Lorsch J
bioRxiv
. 2023 Nov;
PMID: 37986768
We have developed a deep sequencing-based approach, Rec-Seq, that allows simultaneous monitoring of ribosomal 48S pre-initiation complex (PIC) formation on every mRNA in the translatome in an in vitro reconstituted...
3.
Shao Y, Huang H, Qin D, Li N, Koide A, Staley J, et al.
J Mol Biol
. 2016 Sep;
428(20):4100-4114.
PMID: 27593161
Antibodies that bind RNA represent an unrealized source of reagents for synthetic biology and for characterizing cellular transcriptomes. However, facile access to RNA-binding antibodies requires the engineering of effective Fab...
4.
Qin D, Huang L, Wlodaver A, Andrade J, Staley J
RNA
. 2015 Dec;
22(2):237-53.
PMID: 26647463
Pre-mRNA splicing is a central step in the shaping of the eukaryotic transcriptome and in the regulation of gene expression. Yet, due to a focus on fully processed mRNA, common...
5.
Chan Y, Brown M, Qin D, Handa N, Bishop D
J Biol Chem
. 2014 May;
289(26):18076-86.
PMID: 24798326
During meiosis in Saccharomyces cerevisiae, the HOP2 and MND1 genes are essential for recombination. A previous biochemical study has shown that budding yeast Hop2-Mnd1 stimulates the activity of the meiosis-specific...
6.
Qin D, Fredrick K
Methods Enzymol
. 2013 Sep;
530:159-72.
PMID: 24034320
In actively growing cells, the rate of translation initiation is relatively rapid. As a result, multiple ribosomes simultaneously engaged in translation become spaced along single mRNA molecules. These structures, termed...
7.
Fagan C, Dunkle J, Maehigashi T, Dang M, Devaraj A, Miles S, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(24):9716-21.
PMID: 23630274
After four decades of research aimed at understanding tRNA selection on the ribosome, the mechanism by which ribosomal ambiguity (ram) mutations promote miscoding remains unclear. Here, we present two X-ray...
8.
Qin D, Liu Q, Devaraj A, Fredrick K
RNA
. 2012 Jan;
18(3):485-95.
PMID: 22279149
The molecular mechanisms that govern translation initiation to ensure accuracy remain unclear. Here, we provide evidence that the subunit-joining step of initiation is controlled in part by a conformational change...
9.
McClory S, Leisring J, Qin D, Fredrick K
RNA
. 2010 Aug;
16(10):1925-34.
PMID: 20699303
The molecular basis of the induced-fit mechanism that determines the fidelity of protein synthesis remains unclear. Here, we isolated mutations in 16S rRNA that increase the rate of miscoding and...
10.
Qin D, Fredrick K
Mol Microbiol
. 2009 Jan;
71(5):1239-49.
PMID: 19154330
Initiation of translation involves recognition of the start codon by the initiator tRNA in the 30S subunit. To investigate the role of ribosomal RNA (rRNA) in this process, we isolated...