Danislav S Spassov
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Explore the profile of Danislav S Spassov including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Spassov D
Int J Mol Sci
. 2024 Jul;
25(13).
PMID: 39000229
Binding affinity is a fundamental parameter in drug design, describing the strength of the interaction between a molecule and its target protein. Accurately predicting binding affinity is crucial for the...
2.
Spassov D, Atanasova M, Doytchinova I
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542228
Recently, we identified a novel mechanism of enzyme inhibition in N-myristoyltransferases (NMTs), which we have named 'inhibitor trapping'. Inhibitor trapping occurs when the protein captures the small molecule within its...
3.
Spassov D, Atanasova M, Doytchinova I
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511367
Predicting inhibitor potency is critical in drug design and development, yet it has remained one of computational biology's biggest unresolved challenges. Here, we show that in the case of the...
4.
Ruiz-Saenz A, Atreya C, Wang C, Pan B, Dreyer C, Brunen D, et al.
Nat Cancer
. 2023 Feb;
4(2):240-256.
PMID: 36759733
BRAF mutation confers a poor prognosis in metastatic colorectal cancer (CRC) despite combinatorial targeted therapies based on the latest understanding of signaling circuitry. To identify parallel resistance mechanisms induced by...
5.
Spassov D, Atanasova M, Doytchinova I
Front Mol Biosci
. 2023 Jan;
9:1066029.
PMID: 36703920
The salt bridge is the strongest non-covalent interaction in nature and is known to participate in protein folding, protein-protein interactions, and molecular recognition. However, the role of salt bridges in...
6.
Spassov D, Atanasova M, Doytchinova I
Molecules
. 2022 Sep;
27(17).
PMID: 36080246
N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria, and leismaniasis, have also shown great promise as treatment for oncological diseases. The...
7.
Ruiz-Saenz A, Zahedi F, Peterson E, Yoo A, Dreyer C, Spassov D, et al.
Mol Cancer Res
. 2021 Mar;
19(6):957-967.
PMID: 33727342
The Src family kinases (SFK) are homologs of retroviral oncogenes, earning them the label of proto-oncogenes. Their functions are influenced by positive and negative regulatory tyrosine phosphorylation events and inhibitory...
8.
Spassov D, Ruiz-Saenz A, Piple A, Moasser M
Cell Rep
. 2018 Oct;
25(2):449-463.e4.
PMID: 30304684
The mode of regulation of Src kinases has been elucidated by crystallographic studies identifying conserved structured protein modules involved in an orderly set of intramolecular associations and ligand interactions. Despite...
9.
Pollan S, Huang F, Sperger J, Lang J, Morrissey C, Cress A, et al.
Oncogene
. 2018 Mar;
37(21):2817-2836.
PMID: 29511352
Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1...
10.
Enyindah-Asonye G, Li Y, Ruth J, Spassov D, Hebron K, Zijlstra A, et al.
Proc Natl Acad Sci U S A
. 2017 Aug;
114(33):E6912-E6921.
PMID: 28760953
It has been proposed that CD6, an important regulator of T cells, functions by interacting with its currently identified ligand, CD166, but studies performed during the treatment of autoimmune conditions...