Daniel Roderer
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Explore the profile of Daniel Roderer including associated specialties, affiliations and a list of published articles.
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17
Citations
872
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Recent Articles
1.
Nagarajan S, Weber J, Roderer D, Piontek J
Comput Struct Biotechnol J
. 2025 Jan;
27:287-306.
PMID: 39881828
The pore-forming enterotoxin (CPE), a common cause of foodborne diseases, facilitates Ca influx in enterocytes, leading to cell damage. Upon binding to certain claudins (e.g., claudin-4), CPE forms oligomeric pores...
2.
Nganga P, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, et al.
Sci Adv
. 2025 Jan;
11(1):eadr2019.
PMID: 39752508
Tc toxins are pore-forming virulence factors of many pathogenic bacteria. Following pH-induced conformational changes, they perforate the target membrane like a syringe to translocate toxic enzymes into a cell. Although...
3.
Xu Y, Viswanatha R, Sitsel O, Roderer D, Zhao H, Ashwood C, et al.
Nature
. 2022 Sep;
610(7931):349-355.
PMID: 36171290
Entomopathogenic nematodes are widely used as biopesticides. Their insecticidal activity depends on symbiotic bacteria such as Photorhabdus luminescens, which produces toxin complex (Tc) toxins as major virulence factors. No protein...
4.
Belyy A, Lindemann F, Roderer D, Funk J, Bardiaux B, Protze J, et al.
Nat Commun
. 2022 Jul;
13(1):4202.
PMID: 35858890
Tc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of these enzymes is the actin ADP-ribosyltransferase TccC3, whose activity leads to the clustering of the...
5.
Mirgorodskaya E, Dransart E, Shafaq-Zadah M, Roderer D, Sihlbom C, Leffler H, et al.
Biol Cell
. 2022 Mar;
114(6):160-176.
PMID: 35304921
Background Information: Like most other cell surface proteins, α β integrin is glycosylated, which is required for its various activities in ways that mostly remain to be determined. Results: Here,...
6.
Roderer D, Brocker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger P, et al.
Nat Commun
. 2020 Jun;
11(1):2694.
PMID: 32483155
Toxin complex (Tc) toxins are virulence factors of pathogenic bacteria. Tcs are composed of three subunits: TcA, TcB and TcC. TcA facilitates receptor-toxin interaction and membrane permeation, TcB and TcC...
7.
Roderer D, Schubert E, Sitsel O, Raunser S
Nat Commun
. 2019 Nov;
10(1):5263.
PMID: 31748551
Tc toxins are bacterial protein complexes that inject cytotoxic enzymes into target cells using a syringe-like mechanism. Tc toxins are composed of a membrane translocator and a cocoon that encapsulates...
8.
Roderer D, Hofnagel O, Benz R, Raunser S
Proc Natl Acad Sci U S A
. 2019 Nov;
116(46):23083-23090.
PMID: 31666324
Tc toxins are modular toxin systems of insect and human pathogenic bacteria. They are composed of a 1.4-MDa pentameric membrane translocator (TcA) and a 250-kDa cocoon (TcB and TcC) encapsulating...
9.
Wagner T, Merino F, Stabrin M, Moriya T, Antoni C, Apelbaum A, et al.
Commun Biol
. 2019 Jun;
2:218.
PMID: 31240256
Selecting particles from digital micrographs is an essential step in single-particle electron cryomicroscopy (cryo-EM). As manual selection of complete datasets-typically comprising thousands of particles-is a tedious and time-consuming process, numerous ...
10.
Roderer D, Raunser S
Annu Rev Microbiol
. 2019 May;
73:247-265.
PMID: 31140906
Tc toxin complexes are virulence factors of many bacteria, including insect and human pathogens. Tc toxins are composed of three subunits that act together to perforate the host membrane, similar...