Stefan Raunser
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Explore the profile of Stefan Raunser including associated specialties, affiliations and a list of published articles.
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Articles
137
Citations
6407
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Recent Articles
1.
Oosterheert W, Boiero Sanders M, Bieling P, Raunser S
Trends Cell Biol
. 2025 Jan;
PMID: 39848862
The dynamic turnover of actin filaments drives the morphogenesis and migration of all eukaryotic cells. This review summarizes recent insights into the molecular mechanisms of actin polymerization and disassembly obtained...
2.
Manik M, Pan M, Xiao L, Gu W, Kim H, Pospich S, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2418988122.
PMID: 39786929
Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR domain-containing adaptor-inducing interferon-β) and TRAM (TRIF-related adaptor molecule) are...
3.
Nganga P, Folz J, Kucher S, Roderer D, Xu Y, Sitsel O, et al.
Sci Adv
. 2025 Jan;
11(1):eadr2019.
PMID: 39752508
Tc toxins are pore-forming virulence factors of many pathogenic bacteria. Following pH-induced conformational changes, they perforate the target membrane like a syringe to translocate toxic enzymes into a cell. Although...
4.
Boiero Sanders M, Oosterheert W, Hofnagel O, Bieling P, Raunser S
Nat Commun
. 2024 Sep;
15(1):7969.
PMID: 39261469
Actin filament turnover involves subunits binding to and dissociating from the filament ends, with the pointed end being the primary site of filament disassembly. Several molecules modulate filament turnover, but...
5.
Oosterheert W, Boiero Sanders M, Funk J, Prumbaum D, Raunser S, Bieling P
Science
. 2024 Apr;
384(6692):eadn9560.
PMID: 38603491
Formins control the assembly of actin filaments (F-actin) that drive cell morphogenesis and motility in eukaryotes. However, their molecular interaction with F-actin and their mechanism of action remain unclear. In...
6.
Redhardt M, Raunser S, Raisch T
FEBS Lett
. 2024 Mar;
598(8):875-888.
PMID: 38553946
Mammalian Ca-dependent Slo K channels can stably associate with auxiliary γ subunits which fundamentally alter their behavior. By a so far unknown mechanism, the four γ subunits reduce the need...
7.
Polley S, Raisch T, Ghetti S, Korner M, Terbeck M, Grater F, et al.
Nat Struct Mol Biol
. 2024 Mar;
31(6):861-873.
PMID: 38459128
Biorientation of chromosomes during cell division is necessary for precise dispatching of a mother cell's chromosomes into its two daughters. Kinetochores, large layered structures built on specialized chromosome loci named...
8.
Sitsel O, Wang Z, Janning P, Kroczek L, Wagner T, Raunser S
Nat Microbiol
. 2024 Jan;
9(2):390-404.
PMID: 38238469
Disease-causing bacteria secrete numerous toxins to invade and subjugate their hosts. Unlike many smaller toxins, the secretion machinery of most large toxins remains enigmatic. By combining genomic editing, proteomic profiling...
9.
Belyy A, Heilen P, Hagel P, Hofnagel O, Raunser S
Nat Commun
. 2023 Dec;
14(1):8226.
PMID: 38086871
The bacterial Makes caterpillars floppy 1 (Mcf1) toxin promotes apoptosis in insects, leading to loss of body turgor and death. The molecular mechanism underlying Mcf1 intoxication is poorly understood. Here,...
10.
Tamborrini D, Wang Z, Wagner T, Tacke S, Stabrin M, Grange M, et al.
Nature
. 2023 Nov;
623(7988):863-871.
PMID: 37914933
The thick filament is a key component of sarcomeres, the basic units of striated muscle. Alterations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and...