Daniel R Meldrum
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Explore the profile of Daniel R Meldrum including associated specialties, affiliations and a list of published articles.
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155
Citations
3954
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Recent Articles
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Meldrum K, Zhang H, Hile K, Moldower L, Dong Z, Meldrum D
J Biol Chem
. 2012 Oct;
287(48):40391-9.
PMID: 23027874
Background: IL-18 induces profibrotic changes in TECs independent of TGF-β1 activity. Results: IL-18 stimulates the TLR4 promoter via AP-1 activation to increase TLR4 expression in TECs and stimulates profibrotic changes...
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Brewster B, Rouch J, Wang M, Meldrum D
J Surg Res
. 2012 Jun;
177(2):330-3.
PMID: 22703984
Introduction: Mesenchymal stem cell (MSC) therapy improves cardiac function after ischemia/reperfusion injury, but its effectiveness is limited by MSC survival in hypoxic environments. Toll-like receptor 4 (TLR4) contributes to pro-apoptotic...
5.
Herrmann J, Fiege J, Abarbanell A, Weil B, Wang Y, Poynter J, et al.
J Surg Res
. 2012 Feb;
176(2):386-94.
PMID: 22316665
Background: Neonatal mesenchymal stem cells exhibit less cardioprotective potential than their adult counterparts. Transforming growth factor-α (TGF-α) has been shown to stimulate adult stem cell VEGF production, however, it remains...
6.
Wannemuehler T, Manukyan M, Brewster B, Rouch J, Poynter J, Wang Y, et al.
J Surg Res
. 2012 Jan;
173(1):113-26.
PMID: 22225756
Background: Sepsis remains a source of morbidity and mortality in the postoperative patient despite appropriate resuscitative and antimicrobial approaches. Recent research has focused upon additional interventions such as exogenous cell-based...
7.
Luo Y, Wang Y, Poynter J, Manukyan M, Herrmann J, Abarbanell A, et al.
Surgery
. 2011 Nov;
151(3):353-63.
PMID: 22088815
Background: Mesenchymal stem cells (MSCs) improve postischemic myocardial function in part through their secretion of growth factors such as vascular endothelial growth factor (VEGF). Pretreating MSCs with various cytokines or...
8.
Herrmann J, Abarbanell A, Wang Y, Weil B, Poynter J, Manukyan M, et al.
Ann Thorac Surg
. 2011 Sep;
92(5):1719-25.
PMID: 21944441
Background: Transforming growth factor-α (TGF-α) has been shown to augment mesenchymal stem cell-mediated cardioprotection during acute ischemia and reperfusion in isolated heart models. To determine whether this pretreatment strategy would...
9.
Manukyan M, Keck A, Poynter J, Wang Y, Weil B, Abarbanell A, et al.
Surgery
. 2011 Aug;
150(2):339-46.
PMID: 21801969
Background: The activation of the epidermal growth factor family of receptors may improve cardiac protection after injury. One epidermal growth factor family ligand, transforming growth factor-alpha, promotes wound healing in...
10.
Poynter J, Manukyan M, Wang Y, Brewster B, Herrmann J, Weil B, et al.
Surgery
. 2011 Aug;
150(2):278-83.
PMID: 21801965
Background: Stem cells protect the heart from ischemic damage in part by the release of cytoprotective growth factors, particularly vascular endothelial growth factor (VEGF). Production of VEGF is regulated in...