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Daniel R Meldrum

Explore the profile of Daniel R Meldrum including associated specialties, affiliations and a list of published articles. Areas
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Articles 155
Citations 3954
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Recent Articles
11.
Crowe B, Poynter J, Manukyan M, Wang Y, Brewster B, Herrmann J, et al.
Surgery . 2011 Aug; 150(2):191-6. PMID: 21801958
Background: Cytoprotective growth factors such as vascular endothelial growth factor (VEGF) play important roles in myocardial protection from ischemia/reperfusion (I/R). Accumulating evidence suggests that the hypoxia-inducible factor 1 (HIF-1) pathway...
12.
Manukyan M, Alvernaz C, Poynter J, Wang Y, Brewster B, Weil B, et al.
Surgery . 2011 Jul; 150(2):231-9. PMID: 21719057
Background: Cardiac surgery induces the release of inflammatory mediators that can prolong cardiac dysfunction after operative intervention. Interleukin-10 (IL-10), a potent inhibitor of myocardial inflammation, is a known factor in...
13.
Weil B, Herrmann J, Abarbanell A, Manukyan M, Poynter J, Meldrum D
Shock . 2011 Jun; 36(3):235-41. PMID: 21654558
Mesenchymal stem cells (MSCs) possess immunomodulatory properties and may curtail the inflammatory response that characterizes sepsis and other systemic inflammatory states. We aimed to determine whether intravenous infusion of MSCs...
14.
Poynter J, Herrmann J, Manukyan M, Wang Y, Abarbanell A, Weil B, et al.
J Am Coll Surg . 2011 May; 213(2):253-60. PMID: 21546276
Background: Signal transducer and activator of transcription 3 (STAT3) regulates myocardial apoptosis, cellular proliferation, and the immune response after ischemia/reperfusion (I/R). STAT3 is also necessary for the production of vascular...
15.
Manukyan M, Weil B, Wang Y, Abarbanell A, Herrmann J, Poynter J, et al.
Am J Physiol Regul Integr Comp Physiol . 2011 Apr; 300(6):R1506-14. PMID: 21451141
Mesenchymal stem cells (MSCs) may offer therapeutic benefit in the setting of sepsis and endotoxemia. Previous studies suggest that MSCs from female donors may possess better protective capabilities than their...
16.
Herrmann J, Weil B, Abarbanell A, Wang Y, Poynter J, Manukyan M, et al.
Shock . 2011 Jan; 35(5):512-6. PMID: 21263382
Mesenchymal stem cells (MSCs) protect ischemic tissues in part through paracrine growth factor production. IL-6, which is upregulated in the heart during ischemia, has been shown to enhance stem cell...
17.
Wang Y, Abarbanell A, Herrmann J, Weil B, Manukyan M, Poynter J, et al.
PLoS One . 2010 Dec; 5(12):e14206. PMID: 21151968
Background: Bone marrow-derived mesenchymal stem cells (MSC) improve myocardial recovery after ischemia/reperfusion (I/R) injury. These effects are mediated in part by the paracrine secretion of angiogenic and tissue growth-promoting factors....
18.
Poynter J, Beckman D, Abarbanell A, Herrmann J, Manukyan M, Weil B, et al.
Ann Thorac Surg . 2010 Nov; 90(6):2079-86. PMID: 21095380
Atrial fibrillation (AF) is the most common chronic arrhythmia in the United States and is associated with high morbidity rates and significant healthcare costs. Although medical therapy for AF modestly...
19.
Lahm T, McCaslin C, Wozniak T, Ghumman W, Fadl Y, Obeidat O, et al.
J Am Coll Cardiol . 2010 Oct; 56(18):1435-46. PMID: 20951319
Acute right ventricular (RV) failure is a frequent and serious clinical challenge in the intensive care unit. It is usually seen as a consequence of left ventricular failure, pulmonary embolism,...
20.
Weil B, Manukyan M, Herrmann J, Abarbanell A, Poynter J, Wang Y, et al.
J Surg Res . 2010 Sep; 167(1):78-86. PMID: 20869073
Mesenchymal stem cells (MSCs) have been used experimentally and clinically in the treatment of a wide variety of pathologies. It is now clear that a number of different mechanisms contribute...