Daniel R Larson
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Explore the profile of Daniel R Larson including associated specialties, affiliations and a list of published articles.
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64
Citations
4507
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Recent Articles
1.
Sood V, Holewinski R, Andresson T, Larson D, Misteli T
Mol Cell
. 2025 Feb;
85(5):913-928.e8.
PMID: 39978338
Stochastic transcriptional bursting is a universal property of active genes. While different genes exhibit distinct bursting patterns, the molecular mechanisms that govern gene-specific stochastic bursting are largely unknown. We have...
2.
Conway E, Larson D
Curr Opin Struct Biol
. 2024 Dec;
90:102956.
PMID: 39631257
No abstract available.
3.
McGraw K, Larson D
Semin Hematol
. 2024 Nov;
61(6):470-478.
PMID: 39603905
The Myelodysplastic Syndromes (MDS) are heterogeneous stem cell malignancies clinically characterized by bone marrow dysplasia, peripheral blood cytopenias, and a high risk for transformation to acute myeloid leukemia. In early...
4.
Donovan B, Wang B, Garcia G, Mount S, Larson D
bioRxiv
. 2024 Oct;
PMID: 39372787
The spliceosome is a megadalton protein-RNA complex which removes introns from pre-mRNA, yet the dynamic early assembly steps have not been structurally resolved. Specifically, how the spliceosome selects the correct...
5.
Fursova N, Larson D
Curr Opin Struct Biol
. 2024 Sep;
89:102920.
PMID: 39306948
Chromatin organization, facilitated by compartmentalization and loop extrusion, is crucial for proper gene expression and cell viability. Transcription has long been considered important for shaping genome architecture due to its...
6.
Bohrer C, Fursova N, Larson D
ACS Synth Biol
. 2024 Sep;
13(10):3093-3108.
PMID: 39276360
Enhancers are central for the regulation of metazoan transcription but have proven difficult to study, primarily due to a myriad of interdependent variables shaping their activity. Consequently, synthetic biology has...
7.
Trzaskoma P, Jung S, Pekowska A, Bohrer C, Wang X, Naz F, et al.
Sci Adv
. 2024 Aug;
10(32):eadl4893.
PMID: 39121214
Discontinuous transcription is evolutionarily conserved and a fundamental feature of gene regulation; yet, the exact mechanisms underlying transcriptional bursting are unresolved. Analyses of bursting transcriptome-wide have focused on the role...
8.
Keikhosravi A, Almansour F, Bohrer C, Fursova N, Guin K, Sood V, et al.
Sci Rep
. 2024 Aug;
14(1):18426.
PMID: 39117696
High-throughput imaging (HTI) generates complex imaging datasets from a large number of experimental perturbations. Commercial HTI software programs for image analysis workflows typically do not allow full customization and adoption...
9.
Shelansky R, Abrahamsson S, Brown C, Doody M, Lenstra T, Larson D, et al.
Nat Commun
. 2024 Jul;
15(1):6226.
PMID: 39043639
Fluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription. In steady state, the regulatory...
10.
Sood V, Holewinski R, Andresson T, Larson D, Misteli T
bioRxiv
. 2024 Jun;
PMID: 38903099
Stochastic transcriptional bursting is a universal property of active genes. While different genes exhibit distinct bursting patterns, the molecular mechanisms for gene-specific stochastic bursting are largely unknown. We have developed...