Daniel R Beisner
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Explore the profile of Daniel R Beisner including associated specialties, affiliations and a list of published articles.
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11
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1003
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Recent Articles
1.
Velcicky J, Mathison C, Nikulin V, Pflieger D, Epple R, Azimioara M, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):887-892.
PMID: 31223443
SPPL2a (Signal Peptide Peptidase Like 2a) is an intramembrane aspartyl protease engaged in the function of B-cells and dendritic cells. Despite being an attractive target for modulation of the immune...
2.
Velcicky J, Bodendorf U, Rigollier P, Epple R, Beisner D, Guerini D, et al.
J Med Chem
. 2018 Jan;
61(3):865-880.
PMID: 29359565
Signal peptide peptidase-like 2a (SPPL2a) is an aspartic intramembrane protease which has recently been shown to play an important role in the development and function of antigen presenting cells such...
3.
Miller A, Dahlberg C, Sandberg M, Wen B, Beisner D, Hoerter J, et al.
PLoS One
. 2015 Jun;
10(6):e0131071.
PMID: 26121493
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of...
4.
Beisner D, Langerak P, Parker A, Dahlberg C, Otero F, Sutton S, et al.
J Exp Med
. 2012 Dec;
210(1):23-30.
PMID: 23267013
B cell development requires tight regulation to allow for the generation of a diverse repertoire while preventing the development of autoreactive cells. We report, using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis, the identification...
5.
Kerdiles Y, Stone E, Beisner D, Beisner D, McGargill M, Chen I, et al.
Immunity
. 2010 Dec;
33(6):890-904.
PMID: 21167754
Foxo transcription factors integrate extrinsic signals to regulate cell division, differentiation and survival, and specific functions of lymphoid and myeloid cells. Here, we showed the absence of Foxo1 severely curtailed...
6.
Dejean A, Beisner D, Chen I, Kerdiles Y, Babour A, Arden K, et al.
Nat Immunol
. 2009 Apr;
10(5):504-13.
PMID: 19363483
Foxo transcription factors regulate cell cycle progression, cell survival and DNA-repair pathways. Here we demonstrate that deficiency in Foxo3 resulted in greater expansion of T cell populations after viral infection....
7.
Miller A, Beisner D, Liu D, Cooke M
J Immunol
. 2009 Apr;
182(8):4696-704.
PMID: 19342645
Inositol 1,4,5-trisphosphate 3-kinase B (or Itpkb) converts inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetrakisphosphate upon Ag receptor activation and controls the fate and function of lymphocytes. To determine the role of Itpkb...
8.
Kerdiles Y, Beisner D, Tinoco R, Dejean A, Castrillon D, DePinho R, et al.
Nat Immunol
. 2009 Jan;
10(2):176-84.
PMID: 19136962
Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role...
9.
Chen I, Beisner D, Degterev A, Lynch C, Yuan J, Hoffmann A, et al.
Proc Natl Acad Sci U S A
. 2008 Nov;
105(45):17463-8.
PMID: 18981423
T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in...
10.
Beisner D, Chen I, Kolla R, Hoffmann A, Hedrick S
J Immunol
. 2005 Sep;
175(6):3469-73.
PMID: 16148088
Caspase-8 is an essential component of death receptor-mediated apoptosis. Along with Fas-associated death domain protein, it is also essential for T cell proliferation in response to antigenic or mitogenic stimuli....