Daniel Metzger
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Explore the profile of Daniel Metzger including associated specialties, affiliations and a list of published articles.
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182
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Recent Articles
11.
Ghaibour K, Schuh M, Souali-Crespo S, Chambon C, Charlot A, Rizk J, et al.
J Cachexia Sarcopenia Muscle
. 2023 May;
14(4):1707-1720.
PMID: 37208984
Background: Androgens are anabolic steroid hormones that exert their function by binding to the androgen receptor (AR). We have previously established that AR deficiency in limb muscles impairs sarcomere myofibrillar...
12.
Terzic J, Abu El Maaty M, Lutzing R, Vincent A, El Bizri R, Jung M, et al.
EMBO Mol Med
. 2023 Apr;
15(6):e17209.
PMID: 37070472
Androgen deprivation therapy (ADT) is a cornerstone of prostate cancer (PCa) management. Although tumors initially regress, many progress to a hormone-independent state termed castration-resistant PCa (CRPC), for which treatment options...
13.
Belorusova A, Rovito D, Chebaro Y, Doms S, Verlinden L, Verstuyf A, et al.
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955580
The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been...
14.
Abu El Maaty M, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, et al.
Sci Adv
. 2022 Jul;
8(29):eabo2295.
PMID: 35867798
Prostate cancer (PCa) is a leading cause of cancer-related deaths. The slow evolution of precancerous lesions to malignant tumors provides a broad time frame for preventing PCa. To characterize prostatic...
15.
Oppong-Gyebi A, Metzger D, Vann P, Yockey R, Sumien N, Schreihofer D
Horm Behav
. 2022 Jun;
144:105201.
PMID: 35653830
Genistein possesses estrogenic activity and has been considered a potential replacement for estrogen replacement therapy after menopause. In the current study, we investigated the neuroprotective effects of dietary genistein at...
16.
Ayub A, Ng C, Portales-Casamar E, Metzger D, Amed S
Can J Diabetes
. 2022 May;
46(4):346-352.e1.
PMID: 35527205
Objectives: Pediatric diabetes health-care providers and decision-makers in British Columbia (BC) have prioritized the creation of a provincial pediatric diabetes clinical registry to improve care quality. Our objective is to...
17.
Farfariello V, Gordienko D, Mesilmany L, Touil Y, Germain E, Fliniaux I, et al.
Nat Commun
. 2022 Feb;
13(1):956.
PMID: 35177596
Cellular senescence is implicated in a great number of diseases including cancer. Although alterations in mitochondrial metabolism were reported as senescence drivers, the underlying mechanisms remain elusive. We report the...
18.
Satapati S, Downes D, Metzger D, Shankaran H, Talukdar S, Zhou Y, et al.
SLAS Discov
. 2022 Jan;
27(1):20-28.
PMID: 35058172
Screening campaigns, especially those aimed at modulating enzyme activity, often rely on measuring substrate→product conversions. Unfortunately, the presence of endogenous substrates and/or products can limit one's ability to measure conversions....
19.
Oppong-Gyebi A, Metzger D, Doan T, Han J, Vann P, Yockey R, et al.
J Neurosci Res
. 2021 Oct;
100(2):598-619.
PMID: 34713481
Increasing age disproportionately increases the risk of stroke among women compared to men of similar age, especially after menopause. One of the reasons for this observation is a sharp drop...
20.
Vachal P, Duffy J, Campeau L, Amin R, Mitra K, Murphy B, et al.
J Med Chem
. 2021 Aug;
64(18):13215-13258.
PMID: 34375108
Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased...