Daniel M Kemp
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Explore the profile of Daniel M Kemp including associated specialties, affiliations and a list of published articles.
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833
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Recent Articles
1.
Muise E, Guan H, Liu J, Nawrocki A, Yang X, Wang C, et al.
PLoS One
. 2019 Feb;
14(2):e0211568.
PMID: 30811418
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in...
2.
Myers R, Guan H, Ehrhart J, Petrov A, Prahalada S, Tozzo E, et al.
Science
. 2017 Jul;
357(6350):507-511.
PMID: 28705990
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. Despite three decades of investigation, the biological roles of AMPK and its potential as a drug...
3.
Kemp D
Adipocyte
. 2013 Aug;
2(3):188-90.
PMID: 23991367
Recent studies, including one from our own lab, report that different subpopulations of obese individuals display a variable inflammatory signature in their visceral adipose tissue that may contribute significantly to...
4.
Lee J, Gao J, Kosinski P, Elliman S, Hughes T, Gromada J, et al.
Biochem Biophys Res Commun
. 2012 Dec;
430(3):1109-13.
PMID: 23261432
The cytoprotective stress response factor HSF1 regulates the transcription of the chaperone HSP70, which exhibits anti-inflammatory effects and improves insulin sensitivity. We tested the therapeutic potential of this pathway in...
5.
Tu Z, Keller M, Zhang C, Rabaglia M, Greenawalt D, Yang X, et al.
PLoS Genet
. 2012 Dec;
8(12):e1003107.
PMID: 23236292
Complex diseases result from molecular changes induced by multiple genetic factors and the environment. To derive a systems view of how genetic loci interact in the context of tissue-specific molecular...
6.
Qatanani M, Tan Y, Dobrin R, Greenawalt D, Hu G, Zhao W, et al.
Diabetes
. 2012 Dec;
62(3):855-63.
PMID: 23223024
Obesity is associated with insulin resistance, a major risk factor for type 2 diabetes and cardiovascular disease. However, not all obese individuals are insulin resistant, which confounds our understanding of...
7.
Dobrin R, Greenawalt D, Hu G, Kemp D, Kaplan L, Schadt E, et al.
PLoS One
. 2011 Sep;
6(8):e23480.
PMID: 21912597
Complex diseases such as obesity and type II diabetes can result from a failure in multiple organ systems including the central nervous system and tissues involved in partitioning and disposal...
8.
A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort
Greenawalt D, Dobrin R, Chudin E, Hatoum I, Suver C, Beaulaurier J, et al.
Genome Res
. 2011 May;
21(7):1008-16.
PMID: 21602305
To map the genetics of gene expression in metabolically relevant tissues and investigate the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we collected four tissues...
9.
Szustakowski J, Kosinski P, Marrese C, Lee J, Elliman S, Nirmala N, et al.
BMC Mol Biol
. 2007 Jun;
8:46.
PMID: 17550601
Background: Using a gene clustering strategy we determined intracellular pathway relationships within skeletal myotubes in response to an acute heat stress stimuli. Following heat shock, the transcriptome was analyzed by...
10.
Kemp D, Nirmala N, Szustakowski J
Bioinformatics
. 2007 Mar;
23(11):1356-62.
PMID: 17392327
Motivation: We describe an extension of the pathway-based enrichment approach for analyzing microarray data via a robust test for transcriptional variance. The use of a variance test is intended to...