Daniel J Urban
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Explore the profile of Daniel J Urban including associated specialties, affiliations and a list of published articles.
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39
Citations
1936
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Recent Articles
1.
Antignani A, Bilotta M, Roth J, Urban D, Shen M, Hall M, et al.
FASEB J
. 2023 Nov;
37(12):e23292.
PMID: 37971407
Immunotoxins (ITs) target cancer cells via antibody binding to surface antigens followed by internalization and toxin-mediated inhibition of protein synthesis. The fate of cells responding to IT treatment depends on...
2.
Anthwal N, Urban D, Sadier A, Takenaka R, Spiro S, Simmons N, et al.
BMC Biol
. 2023 May;
21(1):101.
PMID: 37143038
Background: Through the evolution of novel wing structures, bats (Order Chiroptera) became the only mammalian group to achieve powered flight. This achievement preceded the massive adaptive radiation of bats into...
3.
White H, Tucker A, Fernandez V, Portela Miguez R, Hautier L, Herrel A, et al.
Curr Biol
. 2023 Apr;
33(11):2136-2150.e4.
PMID: 37119816
Within mammals, different reproductive strategies (e.g., egg laying, live birth of extremely underdeveloped young, and live birth of well-developed young) have been linked to divergent evolutionary histories. How and when...
4.
Sulser R, Patterson B, Urban D, Neander A, Luo Z
Nature
. 2022 Jan;
602(7897):449-454.
PMID: 35082447
Phylogenomics of bats suggests that their echolocation either evolved separately in the bat suborders Yinpterochiroptera and Yangochiroptera, or had a single origin in bat ancestors and was later lost in...
5.
Rohde J, Karavadhi S, Pragani R, Liu L, Fang Y, Zhang W, et al.
J Med Chem
. 2021 Apr;
64(8):4913-4946.
PMID: 33822623
Neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) are oncogenic for a number of malignancies, primarily low-grade gliomas and acute myeloid leukemia. We report a medicinal chemistry campaign around a 7,7-dimethyl-7,8-dihydro-2-1λ-quinoline-2,5(6)-dione...
6.
Christov P, Kim K, Jana S, Romaine I, Rai G, Mott B, et al.
Bioorg Med Chem Lett
. 2021 Mar;
41:127974.
PMID: 33771585
Lactate dehydrogenase (LDH) is a critical enzyme in the glycolytic metabolism pathway that is used by many tumor cells. Inhibitors of LDH may be expected to inhibit the metabolic processes...
7.
Sadier A, Urban D, Anthwal N, Howenstine A, Sinha I, Sears K
Genet Mol Biol
. 2021 Feb;
43(1 Suppl 2):e20190146.
PMID: 33576369
Bats are incredibly diverse, both morphologically and taxonomically. Bats are the only mammalian group to have achieved powered flight, an adaptation that is hypothesized to have allowed them to colonize...
8.
Rai G, Urban D, Mott B, Hu X, Yang S, Benavides G, et al.
J Med Chem
. 2020 Sep;
63(19):10984-11011.
PMID: 32902275
Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the glycolytic pathway. Glycolysis plays an important...
9.
Fleming B, Urban D, Hall M, Longerich T, Greten T, Pastan I, et al.
Hepatology
. 2019 Sep;
71(5):1696-1711.
PMID: 31520528
Background And Aims: Treatment of hepatocellular carcinomas using our glypican-3 (GPC3)-targeting human nanobody (HN3) immunotoxins causes potent tumor regression by blocking protein synthesis and down-regulating the Wnt signaling pathway. However,...
10.
Yeung C, Gibson A, Issaq S, Oshima N, Baumgart J, Edessa L, et al.
Cancer Res
. 2019 Aug;
79(19):5060-5073.
PMID: 31431459
Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly a century ago, effective therapeutic...