Daniel J Orton
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Explore the profile of Daniel J Orton including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Ye Y, Swensen A, Wang Y, Kaushal M, Salamon D, Knoten A, et al.
Kidney Int Rep
. 2021 Oct;
6(12):3064-3069.
PMID: 34642644
No abstract available.
12.
Martin K, Zhang T, Lin T, Habowski A, Zhao R, Tsai C, et al.
J Proteome Res
. 2021 Aug;
20(9):4452-4461.
PMID: 34351778
Recent advances in sample preparation enable label-free mass spectrometry (MS)-based proteome profiling of small numbers of mammalian cells. However, specific devices are often required to downscale sample processing volume from...
13.
Nakayasu E, Gritsenko M, Piehowski P, Gao Y, Orton D, Schepmoes A, et al.
Nat Protoc
. 2021 Jul;
16(8):3737-3760.
PMID: 34244696
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new disease biomarkers. However, certain critical steps of study design such as cohort selection, evaluation of statistical power, sample blinding and...
14.
Lee J, Bilbao A, Conant C, Bloodsworth K, Orton D, Zhou M, et al.
Bioinformatics
. 2021 Jun;
37(22):4193-4201.
PMID: 34145874
Motivation: Ion mobility spectrometry (IMS) separations are increasingly used in conjunction with mass spectrometry (MS) for separation and characterization of ionized molecular species. Information obtained from IMS measurements includes the...
15.
Gao Y, Fillmore T, Munoz N, Bentley G, Johnson C, Kim J, et al.
Front Bioeng Biotechnol
. 2021 Jan;
8:603488.
PMID: 33425868
Targeted proteomics is a mass spectrometry-based protein quantification technique with high sensitivity, accuracy, and reproducibility. As a key component in the multi-omics toolbox of systems biology, targeted liquid chromatography-selected reaction...
16.
Li A, Conant C, Zheng X, Bloodsworth K, Orton D, Garimella S, et al.
Anal Chem
. 2020 Nov;
92(22):14976-14982.
PMID: 33136380
The collision cross section (CCS) is an important property that aids in the structural characterization of molecules. Here, we investigated the CCS calibration accuracy with traveling wave ion mobility spectrometry...
17.
Williams S, Liyu A, Tsai C, Moore R, Orton D, Chrisler W, et al.
Anal Chem
. 2020 Jul;
92(15):10588-10596.
PMID: 32639140
Single-cell proteomics can provide critical biological insight into the cellular heterogeneity that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet processing in one pot for trace samples)...
18.
Piehowski P, Zhu Y, Bramer L, Stratton K, Zhao R, Orton D, et al.
Nat Commun
. 2020 Jan;
11(1):8.
PMID: 31911630
Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is...
19.
Wakasaki R, Matsushita K, Golgotiu K, Anderson S, Eiwaz M, Orton D, et al.
JCI Insight
. 2019 Mar;
4(4).
PMID: 30829647
Acute cardiorenal syndrome (CRS-1) is a morbid complication of acute cardiovascular disease. Heart-to-kidney signals transmitted by "cardiorenal connectors" have been postulated, but investigation into CRS-1 has been limited by technical...
20.
Matsushita K, Golgotiu K, Orton D, Smith R, Rodland K, Piehowski P, et al.
J Vis Exp
. 2018 Oct;
(140).
PMID: 30371667
Renal micropuncture and renal 2-photon imaging are seminal techniques in renal physiology. However, micropuncture is limited by dependence on conventional microscopy to surface nephron features, and 2-photon studies are limited...