Daniel J Orton
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Explore the profile of Daniel J Orton including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Kitata R, Velickovic M, Xu Z, Zhao R, Scholten D, Chu R, et al.
Nat Commun
. 2025 Jan;
16(1):547.
PMID: 39805815
With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. However, such bulk measurement lacks spatial resolution and obscures tissue heterogeneity, precluding proteome mapping of...
2.
Ross D, Bredeweg E, Eder J, Orton D, Burnet M, Kyle J, et al.
J Mass Spectrom
. 2024 Aug;
59(9):e5078.
PMID: 39132905
Understanding fungal lipid biology and metabolism is critical for antifungal target discovery as lipids play central roles in cellular processes. Nuances in lipid structural differences can significantly impact their functions,...
3.
Harrison A, Eder J, Lalli P, Munoz N, Gao Y, Clendinen C, et al.
J Am Soc Mass Spectrom
. 2024 Jul;
35(11):2680-2689.
PMID: 39013167
Mass spectrometry is broadly employed to study complex molecular mechanisms in various biological and environmental fields, enabling 'omics' research such as proteomics, metabolomics, and lipidomics. As study cohorts grow larger...
4.
Kitata R, Velickovic M, Xu Z, Zhao R, Scholten D, Chu R, et al.
bioRxiv
. 2023 Aug;
PMID: 37645907
With advanced mass spectrometry (MS)-based proteomics, genome-scale proteome coverage can be achieved from bulk tissues. However, such bulk measurement lacks spatial resolution and obscures important tissue heterogeneity, which make it...
5.
Nakayasu E, Bramer L, Ansong C, Schepmoes A, Fillmore T, Gritsenko M, et al.
Cell Rep Med
. 2023 Jun;
4(7):101093.
PMID: 37390828
Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase...
6.
Thibert S, Bracken C, Orton D, Gibbons B, Zhou M
J Am Soc Mass Spectrom
. 2023 Jun;
34(7):1528-1531.
PMID: 37291876
High throughput native mass spectrometry analysis of proteins and protein complexes has been enabled by recent development of infusion and liquid chromatography (LC) systems, which often include complete LC pumps...
7.
Bilbao A, Munoz N, Kim J, Orton D, Gao Y, Poorey K, et al.
Nat Commun
. 2023 Apr;
14(1):2461.
PMID: 37117207
Multidimensional measurements using state-of-the-art separations and mass spectrometry provide advantages in untargeted metabolomics analyses for studying biological and environmental bio-chemical processes. However, the lack of rapid analytical methods and robust...
8.
Ross D, Lee J, Bilbao A, Orton D, Eder J, Burnet M, et al.
Commun Chem
. 2023 Apr;
6(1):74.
PMID: 37076550
Lipids play essential roles in many biological processes and disease pathology, but unambiguous identification of lipids is complicated by the presence of multiple isomeric species differing by fatty acyl chain...
9.
Bhattacharjee A, Qafoku O, Richardson J, Anderson L, Schwarz K, Bramer L, et al.
mSystems
. 2022 Nov;
7(6):e0091322.
PMID: 36394319
Soil fungi facilitate the translocation of inorganic nutrients from soil minerals to other microorganisms and plants. This ability is particularly advantageous in impoverished soils because fungal mycelial networks can bridge...
10.
Colby S, Chang C, Bade J, Nunez J, Blumer M, Orton D, et al.
Anal Chem
. 2022 Apr;
94(16):6130-6138.
PMID: 35430813
We present DEIMoS: Data Extraction for Integrated Multidimensional Spectrometry, a Python application programming interface (API) and command-line tool for high-dimensional mass spectrometry data analysis workflows that offers ease of development...