Daniel Herp
Overview
Explore the profile of Daniel Herp including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
261
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Darwish S, Heimburg T, Ridinger J, Herp D, Schmidt M, Romier C, et al.
Methods Mol Biol
. 2022 Oct;
2589:179-193.
PMID: 36255625
Histone deacetylases are considered promising epigenetic targets for chemical protein degradation due to their diverse roles in physiological cellular functions and in the diseased state. Proteolysis-targeting chimeras (PROTACs) are bifunctional...
2.
Darwish S, Ghazy E, Heimburg T, Herp D, Zeyen P, Salem-Altintas R, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886887
In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated...
3.
Herp D, Ridinger J, Robaa D, Shinsky S, Schmidtkunz K, Yesiloglu T, et al.
Chembiochem
. 2022 May;
23(14):e202200180.
PMID: 35608330
Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the...
4.
Federico S, Khan T, Fontana A, Brogi S, Benedetti R, Sarno F, et al.
Eur J Med Chem
. 2022 May;
238:114409.
PMID: 35551034
The search of new therapeutic tools for the treatment of cancer is being a challenge for medicinal chemists. Due to their role in different pathological conditions, histone deacetylase (HDAC) enzymes...
5.
Zeyen P, Zeyn Y, Herp D, Mahmoudi F, Yesiloglu T, Erdmann F, et al.
Eur J Med Chem
. 2022 Mar;
234:114272.
PMID: 35306288
Histone deacetylases (HDACs) are a family of 18 epigenetic modifiers that fall into 4 classes. Histone deacetylase inhibitors (HDACi) are valid tools to assess HDAC functions. HDAC6 and HDAC10 belong...
6.
Marek M, Ramos-Morales E, Picchi-Constante G, Bayer T, Norstrom C, Herp D, et al.
Cell Rep
. 2021 Dec;
37(12):110129.
PMID: 34936867
Writing and erasing of posttranslational modifications are crucial to phenotypic plasticity and antigenic variation of eukaryotic pathogens. Targeting pathogens' modification machineries, thus, represents a valid approach to fighting parasitic diseases....
7.
Campiani G, Cavella C, Osko J, Brindisi M, Relitti N, Brogi S, et al.
J Med Chem
. 2021 Jul;
64(14):9960-9988.
PMID: 34251197
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities confirmed by our immunohistochemistry studies on HDAC6 overexpression...
8.
Saraswati A, Relitti N, Brindisi M, Osko J, Chemi G, Federico S, et al.
ACS Med Chem Lett
. 2020 Nov;
11(11):2268-2276.
PMID: 33214839
Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-selective...
9.
Relitti N, Saraswati A, Chemi G, Brindisi M, Brogi S, Herp D, et al.
Eur J Med Chem
. 2020 Nov;
212:112998.
PMID: 33199154
In this work we describe the synthesis of potent and selective quinolone-based histone deacetylase 6 (HDAC6) inhibitors. The quinolone moiety has been exploited as an innovative bioactive cap-group for HDAC6...
10.
Brosowsky J, Lutterbeck M, Liebich A, Keller M, Herp D, Vogelmann A, et al.
Chemistry
. 2020 Jul;
26(69):16241-16245.
PMID: 32725698
New Thailandepsin B pseudo-natural products have been prepared. Our synthetic strategy offers the possibility to introduce varying warheads via late stage modification. Additionally, it gives access to the asymmetric branched...