Daniel G Kavanagh
Overview
Explore the profile of Daniel G Kavanagh including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2033
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0
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Recent Articles
1.
Monel B, Lamothe P, Meyo J, McLean A, Quinones-Alvarado R, Laporte M, et al.
bioRxiv
. 2025 Feb;
PMID: 39896504
Efficient recognition and elimination of HIV-1-infected CD4 T cells by cytotoxic CD8 T cells (CTLs) require target cell engagement and the formation of a well-organized immunological synapse. Surface proteins belonging...
2.
Gandhi R, Kwon D, Macklin E, Shopis J, McLean A, McBrine N, et al.
J Acquir Immune Defic Syndr
. 2015 Sep;
71(3):246-53.
PMID: 26379068
Background: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with viral mRNA...
3.
Porichis F, Hart M, Griesbeck M, Everett H, Hassan M, Baxter A, et al.
Nat Commun
. 2014 Dec;
5:5641.
PMID: 25472703
Fluorescent in situ hybridization (FISH) is a method that uses fluorescent probes to detect specific nucleic acid sequences at the single-cell level. Here we describe optimized protocols that exploit a...
4.
Dinter J, Gourdain P, Lai N, Duong E, Bracho-Sanchez E, Rucevic M, et al.
J Immunol
. 2014 Sep;
193(9):4322-4334.
PMID: 25230751
Dendritic cells (DCs), macrophages (MPs), and monocytes are permissive to HIV. Whether they similarly process and present HIV epitopes to HIV-specific CD8 T cells is unknown despite the critical role...
5.
Porichis F, Hart M, Zupkosky J, Barblu L, Kwon D, McMullen A, et al.
J Virol
. 2013 Dec;
88(5):2508-18.
PMID: 24352453
Unlabelled: Antigen persistence in chronic infections and cancer upregulates inhibitory networks, such as the PD-1 and interleukin-10 (IL-10) pathways, that impair immunity and lead to disease progression. These pathways are...
6.
Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells
Pacheco Y, McLean A, Rohrbach J, Porichis F, Kaufmann D, Kavanagh D
J Immunol
. 2013 Aug;
191(5):2072-81.
PMID: 23913963
Various cosignaling molecules on T cells can contribute to activation, inhibition, or exhaustion, depending on context. The surface receptor signaling lymphocytic activation molecule (SLAM) family receptor CD244 (2B4/SLAMf4) has been...
7.
Zhang S, Martin E, Shimada M, Godfrey S, Fricke J, Locastro S, et al.
J Immunol
. 2012 May;
188(12):5924-34.
PMID: 22586036
Viruses evade immune detection partly through immune-associated mutations. Analyses of HIV sequences derived from infected individuals have identified numerous examples of HLA-associated mutations within or adjacent to T cell epitopes,...
8.
Kwon D, Angin M, Hongo T, Law K, Johnson J, Porichis F, et al.
J Virol
. 2012 Apr;
86(12):6586-94.
PMID: 22496237
T cell dysfunction in the presence of ongoing antigen exposure is a cardinal feature of chronic viral infections with persistent high viremia, including HIV-1. Although interleukin-10 (IL-10) has been implicated...
9.
Porichis F, Kwon D, Zupkosky J, Tighe D, McMullen A, Brockman M, et al.
Blood
. 2011 Jun;
118(4):965-74.
PMID: 21652684
Defining the T helper functions impaired by programmed death-1 (PD-1) is crucial for understanding its role in defective HIV control and determining the therapeutic potential of targeting this inhibitory pathway....
10.
Su X, Fricke J, Kavanagh D, Irvine D
Mol Pharm
. 2011 Mar;
8(3):774-87.
PMID: 21417235
Biodegradable core--shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based...